Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 8, and page :100 - 103

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Original Article :

Comparison of fugl-meyer score between patients with acute thrombotic infarc stroke treated with standard medication and fluoxetine

Author :

  1. Wardah Rahmatul Islamiyah*1
  2. Hendro Susilo*2
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Fluoxetine, an inhibitor of serotonin (5-HT) reuptake, increases activation in executive motor areas of healthy subjects. Acute singledose 20 mg administration will increase extracellular 5-HT level in frontal cortex. Fluoxetine also inhibit calcium influx in smoothmuscle vessels. All of that will increase cerebral blood flow and serotonergic transmission in motor cortex. The objective of theresearch is to prove benefits of combination treatment (standard, physical treatment and fluoxetine) than standard treatment onimproving motor deficit in cerebral infarction patient. The study was performed at neurological patient in ward A Dr. SoetomoHospital from February 12th, 2009 until May 12th, 2009. The study sample was acute cerebral infarction patients that fulfilled bothinclusion and exclusion criteria. By using prospective single blind randomization, we performed motor examination (with motorFugl-Meyer scoring) on both groups before and after treatment. The comparison result was analyzed by Mann-Whitney test. Thereare median motor Fugl-Meyer scale improvement in both groups on day 5th, but the improvement is better in fluoxetine groupstatistically significant (p=0.025). Time of administration didn’t influence on treatment effects. Fluoxetine administration besidestandard treatment could increase motor outcome (motor Fugl-Meyer scale) in acute cerebral infarction patients (onset < 72 hours)significantly. (FMI 2014;50:100-103)

Keyword :

fluoxetine, serotonin, motor system, cerebral infarction,

References :

Duncan PW, Goldstein LB, Matchar D, et al,(1992) Measurement of motor recovery after stroke. Outcome assessment and sample size requirements - : Stroke

Loubinoux I, Pariente J, Rascol O, et al,(2002) Selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. A doubleblind, placebo-controlled, multi-dose study in healthy subjects - : Neuropsychologia

Archive Article

Cover Media Content

Volume : 50 / No. : 2 / Pub. : 2014-04
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