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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 4 / Published : 2014-10

TOC : 6, and page :234 - 238

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Original Article :

Comparison of functional improvement scale (nihss) degree between acute intracerebral hemorrhage stroke patients receiving standard treatment and those receiving standard treatment plus celecoxib

Author :

  1. Yudhi Adrianto*1
  2. Hendro Susilo*2
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Intracerebral hemorrhage (ICH) is one of the most devastating types of stroke and is associated with high mortality and morbidity.Several clinical trials were performing to improve clinical outcome through neuroprotection pathway. Celecoxib, one of selectivecyclooxygenase-2 inhibitors has been reported to have anti-inflammatory and antiapoptotic effects, as well as to induce betterfunctional recovery in the experimental intracerebral hemorrhage (ICH). The purpose of this study was to investigate the beneficialeffect of celecoxib in intracerebral hemorrhage patient to improvement of functional outcome by measuring the improvement ofNIHSS scale. Study was designed as randomized, double blind, prospective study. This study involving 58 patients, who admittedwithin the two days after the onset, were treated with celecoxib 200mg b.i.d for 10 days. The patients classified based on age, sex,location of hemorrhage, and the initial NIHSS etc. We compared NIHSS change from baseline between the groups. The basiccharacteristics including mean age, sex, risk factors, location of hematoma, laboratory findings, baseline NIHSS had no significantdifference. No treatment-related adverse effect was documented in the celecoxib group. The aggravations of neurologic status,myocardial infarction, cerebral infarction, or death were not found in the celecoxib group. Significant Improvement of the NIHSSscale was found at day 10. Mean delta NIHSS value after 10 days in control group was 2.17, meanwhile treatment group was 2.68 (p< 0.05). The administration of celecoxib in addition to standard treatment in patients with acute intracerebral hemorrhage strokecan improve the clinical functional outcome as measure with NIHSS scale compared with standard treatment. (FMI 2014;50:234-238)

Keyword :

Intracerebral hemorrhage stroke, Celecoxib, NIHSS,


References :

  1. Abd El-Aal SA, El-Sawalhi MM, Seif-El-Nasr M, Kenawy SA, (2012). Effect of celecoxib and L-NAME on global ischemia-reperfusion injury in the rat hippocampus. 36, 385-395 : Drug Chem Toxicol
  2. Choi NK, Park BJ, Jeong SW, Yu KH, Yoon BW , (2008). Nonaspirin nonsteroidal anti-inflammatory drugs and hemorrhagic stroke risk: the Acute Brain Bleeding Analysis study. 39, 845-849 : Stroke


   


Archive Article

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Volume : 50 / No. : 4 / Pub. : 2014-10
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