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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

TOC : 2, and page :86 - 90

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Original Article :

Comparison of the effect of statin types on the reduction of lipid profile and hs-crp inflammatory marker in diabetics with dyslipidemia

Author :

  1. Nur Palestin Ayumuyas*1
  2. Debra Dorotea*2
  3. Budi Suprapti*3
  4. Sony Wibisono*4
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Kedokteran

Abstract :

Elevated inflammation marker C-reactive protein (CRP) is commonly associated with cardiovascular disease. Statins inhibit theenzyme HMG-CoA reductase, which is required for cholesterol biosynthesis and might also exert pleiotropic effects so that beneficialin the prevention of cardiovascular disease. All statins have the same mechanism of action but different in chemical structures,pharmacokinetic profiles, and lipid reducing efficacy. The objective of this study was to compare the efficacy of two statins,atorvastatin and simvastatin to reduce the lipid profiles and inflammation marker Hs-CRP in patient diabetes mellitus type 2 withdyslipidemic. This was a prospective cohort observational study of 18 diabetes dyslipidemia patient taking either simvastatin 20 mg(n = 11 patient) and atorvastatin 10 mg (n = 7 patient) for about 6 weeks. The efficacy of therapy measured by lipid profiles (totalcholesterol, LDL-C and triglyceride) and inflammation marker Hs-CRP. After 6 weeks therapy, lipid profile and inflammationmarker Hs-CRP pre and post therapy of either taking simvastatin 20 mg or atorvastatin 10 mg did not shown the significancedifferent (p > 0.05). There were also no significance different in lipid profiles between the two groups. In the other hand, theinflammation marker Hs-CRP serum of atorvastatin group significantly decrease compared to simvastatin group (p < 0.05). Inconclusion, there were no different in reducing lipid profiles (total cholesterol, LDL-C, and triglyceride) in either patient takingatorvastatin 10 mg or simvastatin 20 mg after six weeks therapy. Atorvastatin decrease the inflammation marker Hs-CRP serumsbetter than simvastatin. (FMI 2015;51:86-90)

Keyword :

simvastatin, atorvastatin, lipid, Hs-CRP, diabetes,

References :

  1. Jialal I, Stein D, Balis D, Grundy SM, Adams-Huet B, Devaraj S , (2001). Effect of hydroxymethyl glutaryl coenzyme a reductase inhibitor therapy on high sensitive C-reactive protein levels. 103, 1933-1935 : Circulation
  2. Kumar A, Singh V , (2010). Atherogenic dyslipidemia and diabetes mellitus: what’s new in the management area? . 6, 665- 669 : Vascular Health and Risk Management


Archive Article

Cover Media Content

Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation of pharmaceutical care in resolving drug problems in type 2 diabetes mellitus
  2. Comparison of the effect of statin types on the reduction of lipid profile and hs-crp inflammatory marker in diabetics with dyslipidemia
  3. Ciprofloxacin is effective in benign prostatic hyperplasia (bph) patients with urethral catheters
  4. Procalcitonin as biomarker of antibiotic effectivity in communityacquired pneumonia
  5. Effect of fursultiamine supplementation on left ventricular ejection fraction (lvef) in grade iii – iv heart failure patients
  6. Diagnostic value of st2 in patients with acute myocardial infarction
  7. Molecular analysis of rpob gene of mycobacterium tuberculosis in patients with suspected pulmonary tuberculosis in surabaya
  8. Liver function tests of patients with dengue fever, dengue hemorrhagic fever and dengue shock syndrome in tropic and infectious disease ward in the department of internal medicine, dr. soetomo hospital, surabaya
  9. Case report: dengue fever with perimyocarditis
  10. Correlation between heat shock protein (hsp) 70 level and left ventricular dysfunction and its effect on cardiovascular and rehospitalization incidence in patients with acute coronary syndrome
  11. Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats
  12. Acetosal resistance in coronary artery disease between and within type 2 diabetes mellitus patients
  13. Immunochromatography method for rotavirus detection provides good accuracy in diagnosis of rotavirus diarrhea in children