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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 2 / Published : 2010-04

TOC : 7, and page :125 - 131

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Original Article :

Correlation between blood serotonin level with consciousness level and depression symptoms in moderate brain injury patients

Author :

  1. Andre Kusuma*1
  2. M. Arifin Parenrengi*2
  3. Margarita Maria Maramis*3
  1. Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya
  2. Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya
  3. Department of Psychiatry, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya

Abstract :

To analyze a correlation between blood serotonin level, level of consciousness after resuscitation, and depression symptoms to reveal pathological neurobiochemistry level on moderate brain injury patients. This study uses analytical prospective with cross sectional design. Blood sample was taken using disposable spuit approximately 5 cc and was kept in the closed container and centrifuged. The temperature was kept at -200C. Serum was used to determine serotonin level in the blood. Blood sample was taken twice: before 24 hrs after brain injury and less than 1 month afterwards. To examine depression level Hamilton Rating Scale for Depression (HAM-D) was used to figure out whether there is depression symptoms after brain injury. Glasgow Coma Scale was used to examine level of consciousness. The statistical analysis using Spearman correlation resulted in rs = 0,295 and p=0,090 (p>0,05), which means that there is no association between consciousness level and serotonin level before 24 hrs after brain injury. The statistical analysis using Spearman correlation resulted in rs = 0,309 and p=0,075 (p>0,05), which means that there is no association between serotonin level one month after injury and depression level. The last, the statistical analysis using Phi coefficient resulted in Phi = 0,342 and p=0,046 (p<0,05), which means that there is correlation between serotonin level one month after injury and occurrence of depression, which means that people with lower level of serotonin have higher occurrence of depression than people with higher level of serotonin. There is no significant correlation between level of consciousness and serotonin level in the blood under 24 hrs after brain injury. There is significant correlation between serotonin level one month after injury and occurrence of depression.

Keyword :

serotonin, Glasgow Coma Scale, depression,


References :

  1. Ashman, TA & Gordon, WA, (2006). Neurobehavioral consequences of taumatic brain injury. - : Mount Sinai J of Med
  2. Kelly, DF, (1996). General principle of head injury management, in RK Narayan, JE Wilberger, JT Povlishock (eds), Neurotrauma, . New York : McGraw-Hill
  3. Krauss, JF , (1996). Epidemiology of brain injury, in RK Narayan, JE Wilberger, JT Povlishock (eds), Neurotrauma . New York : McGraw-Hill


   


Archive Article

Cover Media Content

Volume : 46 / No. : 2 / Pub. : 2010-04
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  5. Differences of epidermal growth factor (egf) concentration between unpreserved and preserved amniotic membrane
  6. Cytotoxicity effect of curcuma aeruginosa extract on fibroblast with mtt assay method
  7. Correlation between blood serotonin level with consciousness level and depression symptoms in moderate brain injury patients
  8. Blood serotonin level with depression situation and neurocognitive as a reflection of neuron condition in six months after moderate brain injury
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  10. Endoscopic finding of upper gastrointesinal bleeding at dr soetomo hospital, surabaya
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