Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 1 / Published : 2010-01

Order : 5, and page :30 - 35

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Original Article :

Correlation between cox-2 expression with histopathological grading in astrocytoma

Author :

  1. Erliano Sufarnap*1
  2. M Sajid Darmadipura*2
  1. Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr.Soetomo General Hospital Surabaya
  2. Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr.Soetomo General Hospital Surabaya

Abstract :

Cox-2 is an isoform of cycloxygenase which probably has a role in the pathogenesis of intracranial astrocytoma. Although the specific mechanisms has not elucidated, cox-2 had been suggested involve in tumor angiogenesis. In many cases of human neoplasm including astrocytoma, cox-2 expression increases  especially in the high proliferation cell type of tumor (malignant type) for instance GBM, despite there are no data showed the correlation between cox-2 expression and histopathological grading. The objective was to prove the correlation between cox-2 expression and  histopathological grading in astrocytoma. It was analytic cross sectional study using  immunohistochemistry for cox-2 in 25 cases of astrocytoma  during January 2003 until March 2007. Data were analyzed by stastistical methods to rule out the correlation between histopathological grading (WHO System), patient age and sex to cox-2 expression. Twenty five pathological materials , exsiced from 25 brain astrocytoma patients who  underwent surgery for brain astrocytoma were evaluated . Their age range from 12 to 62 years , with the means of 33,36. The 31-45 age group was the highest (31 %).The sex ratio was 56 % men and 44 % women. Histopathological grading revealed : Diffuse astrocytoma (WHO Grade II ) 40 %, Anaplastic astrocytoma (WHO GradeIII) 28 %, GBM (WHO Grade IV) 24 %, and Pilocytic astrocytoma(WHO Grade I) 8 %. The highest positive cells for cox-2 were showed in GBM with the mean of 5,802 %, and the lowest were on Pilocytic astrocytoma (WHO Grade I) for 0,194 %. Spearmen correlation analysis shows positive correlation between between cox-2 expression and  histopathological grading in astrocytomas. There is a correlation between cox-2 expression and histopathological grading according to WHO system. There is also correlation between cox-2 expression and patient age. In addition, patient age has a positive correlations to  astrocytoma histopathological grading. This study shows that the higher the cox-2 expression is the higher is  the histopathological grading of astrocytoma and the older patient is  the higher is  histopathological grading of astrocytoma.

Keyword :

astrocytoma, cox-2 expression, immunohistochemistry, histopathological grading,

References :

Chapple, KS, Scott, N, Guillou, PJ, Coletta, PL & Hull MA,(2002) Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas - : J Pathol

Costa, C, Soares, R, Reis-Filho, JS, Leitao, D, Amendoeira, I & Schmitt, FC,(2002) Cyclooxygenase-2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer - : J Clin Pathol

Gonzales, MF,(1995) Classification and pathogenesis of brain tumors, in AH Kaye & ER Law (eds), Brain Tumors: An Encyclopedic Approach Edinburg : Churchill Livingstone

Archive Article

Cover Media Content

Volume : 46 / No. : 1 / Pub. : 2010-01
  1. Comparison Between The Results Of Acid Fast Bacilli Obtained From Spontaneous Sputum With Sputum Induction By Saline 0.9 % And By Salbutamol Nebules In The Diagnosis Of Sputum Smear Negative Pulmonary Tuberculosis
  2. Role Of Free Radicals In Children With Malnutrition
  3. Effect Of Probiotic Administration On The Levels Of Fecal Secretory Immunoglobulin A In Premature Infants
  4. The Implementation Of Hidden Markov Model For Exon Prediction On Dna-gene Plasmodium Falciparum
  5. Correlation Between Cox-2 Expression With Histopathological Grading In Astrocytoma
  6. Effect Of Low Lead Exposure On Gestational Age, Birth Weight And Premature Rupture Of The Membrane
  7. Diagnostic Accuracy Of Pre-operative Fine Needle Aspiration Biopsy In Ameloblastoma
  8. Chemical Analysis Of Loranthaceae Daendropthoe Sp. By Thin Layer Chromatography
  9. Molecular Characterization Of Mexb Gene Fragment In Bandung Isolate Multiresistant Pseudomonas Aeruginosa
  10. Gracilis Muscle Transposition For Traumatic Anal Incontinence A Case Report
  11. Review Article: Management Of Polycystic Ovary Syndrome In Adolescent
  12. The Clinical Features Of Transient Elastography (fibroscan) Examination Among Liver Diseases Patients At Gastroenterohepatology Division Of Dr. Soetomo Hospital, Surabaya