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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

TOC : 1, and page :1 - 5

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Original Article :

Correlation between dengue virus serotype and humoral immune response in pediatric dengue hemorrhagic fever

Author :

  1. Aryati*1
  2. Ety Retno Setyowati*2
  3. Agung Dwi Wahyu W*3
  1. Department of Clinical Pathology, Airlangga University School of Medicine
  2. Department of Clinical Pathology, Airlangga University School of Medicine
  3. Department of Microbiology, Airlangga University School of Medicine, Dengue Study Group, Institute of Tropical Disease, Airlangga University

Abstract :

Dengue hemorrhagic fever (DHF) is an endemic disease caused by dengue virus. The pathogenesis of dengue hemorrhagic fever is still unclear, while virus virulence and heterologous antibody still play important roles in the pathogenesis of dengue haemorrhagic fever. The aim of this study was to find the correlation between dengue virus serotype distribution and humoral immune response on dengue haemorrhagic fever in children. This infection pattern was based on the antibody profile as a humoral immune response in dengue virus infection. Dengue virus serotype examination was done by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), while humoral immune response was done by IgM-IgG Captured ELISA. The result of this study showed that from 35 dengue haemorrhagic fever cases, majority (74.4%) were secondary infection with mild gradation, grade I (48.6%) and grade II (34.4%). Den-3 and Den-4 serotypes were found, Den-3 have mild clinical manifestation, whereas Den-4 has a fatal manifestation as Dengue Shock Syndrome.

Keyword :

Humoral immune response, DHF, DSS, Den,


References :

  1. Gubler DJ, (1998). Dengue and dengue hemorrhagic fever. anonim : Clinical Microbiology Review
  2. Halstead, SB, (1993). Pathophysiology and pathogenesis of dengue haemorrhagic fever. WHO : Monograph on Dengue/Dengue Fever Haemorrhagic Fever


   


Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2008-01
  1. Correlation between dengue virus serotype and humoral immune response in pediatric dengue hemorrhagic fever
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