UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 1 / Published : 2014-01

Order : 5, and page :19 - 24

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Original Article :

Correlation between heart type fatty acid binding protein serum level and soluble st2 in acute coronary syndrome patients

Author :

  1. Dhani Tri Wahyu Nugroho*1
  2. Mohammad Aminuddin*2
  3. Jusak Nugraha*3
  1. Dr Soekandar Hospital
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Heart-type fatty acid-binding protein (H-FABP) is an early marker of myocardial ischemia even in the absence of frank necrosis. HFABPand N-terminal pro-B-type natriuretic peptide had independent prognostic value in addition to troponin and showed goodcorrelation with infarct size. Soluble ST2 is released as a respond of mechanical stress under condition of acute myocardialinfarction and heart failure. ST2 level showed weak correlation with neither NTproBNP. Elevated ST2 concentrations at admissionin the setting of ACS are associated with higher creatine kinase concentrations, large infarct size, lower pre-discharge LVEF andpredicts 30-days occurrence of heart failure or death after myocardial infarction. To analyze correlation between serum level ofHeart Type Fatty Acid Binding Protein(HFABP) and Soluble ST2 on Acute Coronary Syndrome patient. This was a cross-sectionalstudy in ICCU dr Soetomo Hospital. RELIA TM Immunoassay Diagnostic Instrument (SSJ-2) Kit was used to measured HFABP atadmission and baseline soluble ST2 concentrations with Quantikine Human ST2/IL-1 R4 Immunoassay ELISA method. There were34 subject, women and men and mean age was 55 years old. The mean HFABP at admission was 35,203 ng/mL. The mean ofbaseline soluble ST2 at admission was 33.114 ng/mL. There was strong correlation between concentration of HFABP at admisionand baseline soluble ST2 at admission. There was strong correlation between concentrations of serum HFABP and baseline solubleST2. (FMI 2014;50:19-24)

Keyword :

Acute coronary syndrome, HFABP, soluble ST2,


References :

Bayes-Genis A, de Antonio M, Galán A, Sanz H, Urrutia A, Cabanes R, Cano L, González B, Díez C, P,(2012) Combined use of high-sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure - : Eur J Heart Fail

Chan D and Ng LL,(2010) Biomarkers in acute myocardial infarction - : BMC Medicine





Archive Article

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Volume : 50 / No. : 1 / Pub. : 2014-01
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  2. The Depression Profile Of People Living With Hiv/aids (plwha) Receiving Antiretroviral Treatment In Dr. Soetomo Hospital Surabaya
  3. Agreement Between Estimated Apolipoprotein B-100 Concentration And Apolipoprotein B-100 Concentration Measured By Immunoturbidimetric Method
  4. Er, Pr, And Her-2/neu Profile On Young Breast Carcinoma Patients
  5. Correlation Between Heart Type Fatty Acid Binding Protein Serum Level And Soluble St2 In Acute Coronary Syndrome Patients
  6. Correlation Between N-terminal Pro-brain Natriuretic Peptide Level With Dyastolicfunction Echocardiography Parameter In Acute Coronary Syndrome
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