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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 4 / Published : 2014-10

TOC : 4, and page :222 - 225

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Original Article :

Correlation between preprocedural hscrp level and ck-mb ratio pre and post percutaneous coronary intervention as a marker of preprocedural myocardial injury

Author :

  1. Jaka Fadraersada*1
  2. Siti Sjamsiah*2
  3. Budi Baktijasa*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Cardiovascular Intervention Diagnostic Unit, Dr. Soetomo Hospital, Surabaya

Abstract :

Patients with type 2 diabetes mellitus may experience inflammation, shown by increased hsCRP levels. Increased hsCRP beforePercutaneus Coronary Intervention (PCI) is sign of PMI, characterized by increased Creatine Kinase-MB. Increased CK-MB afterPCI increases the death risk, myocardial infarction and revascularization. This study was conducted to find correlation betweenpreprocedural hsCRP levels with changes in ratio of CK-MB levels that indicate PMI. This study was an observational analytic studywith cross sectional approach. Patients who fulfilled the inclusion criteria, blood samples were taken before PCI to measure hsCRPlevels and preCK-MB, and 18-24 hours after PCI to measure levels of CK-MBpost. Preprocedural hsCRP levels high if >3mg/L andlow if ≤ 3mg/L. PMI is indication if patient CK-MB ratio ≥ 3 and there is no indication if CK-MB ratio < 3. Analysis of pre and postmeasures CK-MB levels was performed using paired t test. There were 10 patients who fulfilled the inclusion criteria of study. Sixpatients had high levels of preprocedural hsCRP (3.43 to 22.66 mg/L) and 4 patients had low levels of preprocedural hsCRP (0.49 to2.23 mg/L). After PCI action, CK-MB levels increased, with levels of 1.31±0.96 initial CK-MB ng/mL to 3.64 ± 3.50 ng/mL werestatistically significant (p=0.026). Four patients had indication PMI and 6 patients there was no indication. Correlation test resultbetween preprocedural hsCRP levels with indications Periprocedural Myocardial Injury (PMI) showed coefficien =0.250 and did’ntshow statistical significance (p=0.243). We found no correlation between preprocedural hsCRP levels with indications ofPeriprocedural PMI is based on the ratio of CK-MB levels. (FMI 2014;50:222-225)

Keyword :

stable angina, diabetes mellitus type-2, hsCRP, PCI, CK-MB,


References :

  1. Fraker TD, Fihn SD, Gibbons RJ et al, (2007). Chronic Angina focused update of the ACC/AHA 2002 Guidelines for the Management of Patients with Chronic Stable Angina. 116, 2762-2772 : Circulation
  2. Lansky AJ, Stone GW, (2010). Periprocedural myocardial infarction: prevalence, prognosis, and prevention. 3, 602-610 : Circ Cardiovasc Interv


   


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Volume : 50 / No. : 4 / Pub. : 2014-10
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