Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 3, and page :73 - 80

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Original Article :

Correlation between serum level of heart type fatty acid binding protein (h-fabp) and n-terminal pro-brain natriuretic peptide (nt-probnp) on acute coronary syndrome patient

Author :

  1. Nurwahyudi*1
  2. M. Aminuddin*2
  1. Resident at the Department of Cardiology Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
  2. Dosen Fakultas Kedokteran

Abstract :

Heart-type fatty acid-binding protein (H-FABP) is an early marker of cardiac necrosis and shows good correlation with infarct size.N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) is released as a response of wall stress and myocyte stretch. This study aimsto analyze correlation between serum level of H-FABP and NT-proBNP on acute coronary syndrome (ACS) patients (n=34) inEmergency Department and Coronary Care Unit of Dr. Soetomo General Hospital, Surabaya. H-FABP and NT-proBNPconcentration were measured using RELIA TM Immunoassay Diagnostic Instrument (SSJ-2) Kit with ELISA method on 1 and 6hours after admission. Mean of H-FABP concentration at 1 and 6 hours after admission consecutively were 35.202882 +45.0928572 ng/mL H(1) and 35.907147 + 44.6597609 ng/mL(H6). Mean of NT-proBNP concentration at 1 and 6 hours afteradmission consecutively were 2040.3062 + 4169.89471 pg/mL (N1) and 2683.3376 + 4190.6605 pg/mL (N6). No significantdifferences between H1 and N1; H6 and N6. H1, N1, H6, N6 were significantly higher on myocardial infarct than unstable/stableangina patients. There were positive correlation of H1 and N1 (p=0.014, r=0.419), H6 and N6 (p=0.001; r=0.527). There was apositive correlation between peak H1 and N1 (p=0.000; r=0.570) and between peak H6 and N6 (p=0.027; r=0.378). There wasstrong positive correlation between levels of H-FABP and NT-proBNP on ACS patients. (FMI 2014;50:73-80)

Keyword :

Acute Coronary Syndrome, H-FABP, NT-proBNP,

References :

Cao YM, Hu DY, Yan L,(2005) Plasma concentration of NT-proBNP in patients with acute coronary syndrome correlated with the severity of the diseases? - : Zhonghua Xin Xue Guan Bing Za Zhi

Alhadi HA and Fox KA,(2004) Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein - : QJM

Archive Article

Cover Media Content

Volume : 50 / No. : 2 / Pub. : 2014-04
  1. The Effect Of 3000 Mg Intravenous Vitamin C On Serum Nitric Oxide Level Of Severe Burnt Injury Patients
  2. Correlation Between Plasma Levels Of Interferon And Viral Load In Patients With Hiv Stage 1
  3. Correlation Between Serum Level Of Heart Type Fatty Acid Binding Protein (h-fabp) And N-terminal Pro-brain Natriuretic Peptide (nt-probnp) On Acute Coronary Syndrome Patient
  4. Profile Of Gyra And Gyrb Gene Mutation In Clinical Isolate Of Ciprofloxacin Resistant Pseudomonas Aeruginosa
  5. Effect Of Cardiac Rehabilitation Programs On Functional Capacity Of Post Coronary Revascularization Patient Using Six Minute Walk-test
  6. Correlation Between Tgf-1 Plasma Level And Cd4+ T Lymphocyte Count In Stage I Hiv-infected Patients
  7. The Effect Of 3000 Mg Vitamin C Infusion On Histamine Level Of Severely Burnt Patients
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  11. Case Report: Trunk And Reticular Varicose On A 9-year-old Child
  12. Comparison Of The Apgar Score Of Spontaneous Vaginal Birth And Assisted Birth In Dr. Soetomo Hospital Surabaya
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