UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 2 / Published : 2010-04

Order : 11, and page :150 - 154

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Original Article :

Correlation between tnf-α, il-1β, pge2 and spla2 levels with severity of dengue hemorrhagic fever

Author :

  1. Purwati *1
  2. Endang Retnowati K*2
  1. Department of Internal Medicine, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
  2. Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya

Abstract :

This study  analyzed the correlation between the severity of dengue hemorrhagic fever patients with the immunological profile such as sPLA2,IL-1β, TNF-α, PGE2. This study is a cross sectional observational research performed between February 2009 – November 2009, comprising 45 patients hospitalized in the Tropical-Infection Ward Department of Internal Medicine Dr. Soetomo Hospital. The examinations  of sPLA2 (correlate enzyme assay), IL-1β, TNF-α, PGE2 by EIA method were performed in the Department of Clinical Pathology, Medical Faculty and Institute of Tropical Disease Airlangga University. It was shown that there was no significant influence on the severity of dengue hemorrhagic fever, because there was no linear correlation. In this study, an increased level in grade 2 compared to grade 1 was found, but in grade 3 the level was decreased.Using Anova in this study a significant difference was found only in IL-1β (p=0.000) on the severity of dengue hemorrhagic fever. A significant difference was found in grade 1 and 3 (p=0.040), also in grade 2 and 3 (p=0.040). This condition may be caused by a decrease in the  inflammation process in grade 3, but the severity of dengue hemorrhagis fever could be influenced by virus strains, complement, thromboxane, leucotriene or other factors that could influence endothel permeability and capillary endothel dysfunction causing greater plasma leakage. No correlation was found between sPLA2,IL-1β, TNF-α and PGE2 and the severity of dengue hemorrhagic fever, but in IL-1β a difference was found. this could be caused by a decrease of inflammatory process in grade 3. Further studies with different parameters which can cause the severity of the disease such as virus strains, complemen, thromboxane, leucotriene or other factors have to carried out.

Keyword :

IL-1β , TNF-α , PGE2 , sPLA2 , dengue hemorrhagic fever,


References :

Catharina,(2001) Pathogenesis of dengue hemorrhagic fever and dengue shock syndrome, Dengue Hemorraghic Fever in Indonesia: the role of cytokines in plasma leakage, coagulation and fibrinolysis Dinsdag : Nijmegen University Press

Gill, GV & Beeching, NJ,(2004) Dengue and yellow fever, in GV Gill & NJ Beeching (eds), Tropical Medicine, 5th edn Massachusetts : Blackwell Publishing

Handojo, I,(2003) Imunoasai untuk demam dengue atau demam berdarah dengue, Imunoasai Terapan pada Beberapa Penyakit Infeksi Surabaya : Airlangga University Press





Archive Article

Cover Media Content

Volume : 46 / No. : 2 / Pub. : 2010-04
  1. Polymorphism Of Natural-resistance-associated Macrophage Protein 1 (nramp1) D543n Gene And Expression Of Nramp1 On Lung Tuberculosis Patients And Nurses In Surabaya
  2. 45 Kda Fimbria Protein Of Proteus Mirabilis As Hemagglutinin And Adhesion Protein
  3. Diagnostic Value Of Widal Slide Assay Using One Phage Type Local Antigen Compared With Four Phage Types Local Antigen In Typhoid Fever Patients In Surabaya
  4. Differences Of Tumor Necrosis Factor Alpha (tnf-α) Plasma Concentration In Malaria Patients With Anemia And Without Anemia
  5. Differences Of Epidermal Growth Factor (egf) Concentration Between Unpreserved And Preserved Amniotic Membrane
  6. Cytotoxicity Effect Of Curcuma Aeruginosa Extract On Fibroblast With Mtt Assay Method
  7. Correlation Between Blood Serotonin Level With Consciousness Level And Depression Symptoms In Moderate Brain Injury Patients
  8. Blood Serotonin Level With Depression Situation And Neurocognitive As A Reflection Of Neuron Condition In Six Months After Moderate Brain Injury
  9. Association Between Heart Disease In Pregnancy With Cardiac Events
  10. Endoscopic Finding Of Upper Gastrointesinal Bleeding At Dr Soetomo Hospital, Surabaya
  11. Correlation Between Tnf-α, Il-1β, Pge2 And Spla2 Levels With Severity Of Dengue Hemorrhagic Fever
  12. Case Report: Auditory Neuropathy In Dr. Soetomo Hospital