Folia Medica Indonesiana
ISSN 0303-7932
Vol. 46 / No. 2 / Published : 2010-04
Order : 11, and page :150 - 154
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Original Article :
Correlation between tnf-α, il-1β, pge2 and spla2 levels with severity of dengue hemorrhagic fever
Author :
- Purwati *1
- Endang Retnowati K*2
- Department of Internal Medicine, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
- Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
Abstract :
This study analyzed the correlation between the severity of dengue hemorrhagic fever patients with the immunological profile such as sPLA2,IL-1β, TNF-α, PGE2. This study is a cross sectional observational research performed between February 2009 – November 2009, comprising 45 patients hospitalized in the Tropical-Infection Ward Department of Internal Medicine Dr. Soetomo Hospital. The examinations of sPLA2 (correlate enzyme assay), IL-1β, TNF-α, PGE2 by EIA method were performed in the Department of Clinical Pathology, Medical Faculty and Institute of Tropical Disease Airlangga University. It was shown that there was no significant influence on the severity of dengue hemorrhagic fever, because there was no linear correlation. In this study, an increased level in grade 2 compared to grade 1 was found, but in grade 3 the level was decreased.Using Anova in this study a significant difference was found only in IL-1β (p=0.000) on the severity of dengue hemorrhagic fever. A significant difference was found in grade 1 and 3 (p=0.040), also in grade 2 and 3 (p=0.040). This condition may be caused by a decrease in the inflammation process in grade 3, but the severity of dengue hemorrhagis fever could be influenced by virus strains, complement, thromboxane, leucotriene or other factors that could influence endothel permeability and capillary endothel dysfunction causing greater plasma leakage. No correlation was found between sPLA2,IL-1β, TNF-α and PGE2 and the severity of dengue hemorrhagic fever, but in IL-1β a difference was found. this could be caused by a decrease of inflammatory process in grade 3. Further studies with different parameters which can cause the severity of the disease such as virus strains, complemen, thromboxane, leucotriene or other factors have to carried out.
Keyword :
IL-1β , TNF-α , PGE2 , sPLA2 , dengue hemorrhagic fever,
References :
Catharina,(2001) Pathogenesis of dengue hemorrhagic fever and dengue shock syndrome, Dengue Hemorraghic Fever in Indonesia: the role of cytokines in plasma leakage, coagulation and fibrinolysis Dinsdag : Nijmegen University Press
Gill, GV & Beeching, NJ,(2004) Dengue and yellow fever, in GV Gill & NJ Beeching (eds), Tropical Medicine, 5th edn Massachusetts : Blackwell Publishing
Handojo, I,(2003) Imunoasai untuk demam dengue atau demam berdarah dengue, Imunoasai Terapan pada Beberapa Penyakit Infeksi Surabaya : Airlangga University Press
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Volume : 46 / No. : 2 / Pub. : 2010-04 |
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