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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 4 / Published : 2009-10

TOC : 8, and page :290 - 293

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Original Article :

Correlation of c-erbb2 expression in undifferentiated nasopharyngeal carcinoma and tumor size (t-stage), regional lymphnodes status (n-stage), and radiation response

Author :

  1. Dyah Fauziah*1
  2. Willy Sandhika*2
  3. Faroek Hoesin*3
  1. Department of Anatomic Pathology Faculty of Medicine Airlangga University Dr Soetomo Hospital, Surabaya
  2. Department of Anatomic Pathology Faculty of Medicine Airlangga University Dr Soetomo Hospital, Surabaya
  3. Department of Anatomic Pathology Faculty of Medicine Airlangga University Dr Soetomo Hospital, Surabaya

Abstract :

c-erbB2 oncogene product is a transmembrane protein and is a growth factor receptor. This oncoprotein has been suggested to be a prognostic factor in a variety of human cancers, but its role as a prognostic factor in nasopharyngeal cancer is still controversial. This study was conducted to determine the correlation of c-erbB2 expression with tumor size (T-stage), regional lymph nodes status (N-stage), and radiation response in undifferentiated nasopharyngealcarcinoma. In this retrospective and cross sectional observational study, theauthor retrieved the clinical data about tumor size (T-stage), regional lymph nodes status (N-stage) and tumor radiation response, from the medical records and made immunohistochemical preparation onarchival tissue specimens from 21 patients of undifferentiated nasopharyngeal carcinoma at Dr. Soetomo Hospital, Surabaya during2003. c-erbB2 expression was found in 11 cases (52.4%) of 21 cases. c-erbB2 expression was positive in 28.6% of T2 undifferentiated nasopharyngeal carcinoma, and 64.3% of T4 undifferentiated nasopharyngeal carcinoma. No significant correlation was found between c-erbB2 expression and tumor size (T-stage). c-erbB2 expression in various N-stages were as follows: N0 (80%), N1 (33,3%), N2 (50%), N3 (42,9%). No significant correlation was found between c-erbB2 expression and N-stage. Of 6 cases with poorly radiation response, 83.3% was c-erbB2 positive.However, no significant correlation was found between c-erbB2 expression and tumor radiation response. This study found no correlation of c-erbB2 expression with tumor size (T-stage), regional lymph nodes status (N-stage), and radiation response in undifferentiated nasopharyngeal carcinoma. This showed that c-erbB2 is not a prognostic factor for nasopharyngeal undifferentiated carcinoma. Further investigation is necessary to determine the other prognostic factor for undifferentiated nasopharyngeal carcinoma.

Keyword :

undifferentiated nasopharyngeal carcinoma, c-erbB2, T-stage, N-stage, radiation response,


References :

  1. Cotran RS, Kumar V, Collins T, (2005). Neoplasia, in Robins Pathologic Basis of Disease, 6th edn. . Philadelphia : W.B. Saunders
  2. Hellman S, (2001). Principles of cancer management: radiation therapy, in De Vita VT, Hellman S, Rosenberg SA (eds), Cancer, Principles and Practice of Oncology, 6th edn . Philadelphia : Lippincott Williams and Wilkins


   


Archive Article

Cover Media Content

Volume : 45 / No. : 4 / Pub. : 2009-10
  1. Utilization of extract phaleria (phaleria macrocarpa) as a precaution against carbon tetrachloride induced hepatotoxicity in mice
  2. Effect of transventricular cerebrospinal fluid in patient with severe brain damage with thin acute subdural bleeding. a comparative study with decompression trepanation action
  3. Comparative effectiveness between chlorhexidine gluconate 0.2% and povidone-iodine 1% as an antiseptic to decrease density level of intraoral germs in maxillofacial fracture surgery
  4. Cyclin d1 expression relationship with clinical stage, grading gland metastasis of tumor cells and squamous cell in cervical carcinoma
  5. Identification of fungtional cluster of extract parasite duku (loranthaceae deandropthoe species) with ft-ir spectrometer
  6. Pcr inhibitor contaminant detection from extraction products of resin chelating dna in forensic dna identification
  7. Events and risk factors of developmental disorders in low birth weight babies
  8. Correlation of c-erbb2 expression in undifferentiated nasopharyngeal carcinoma and tumor size (t-stage), regional lymphnodes status (n-stage), and radiation response
  9. Macrophage between the first and third day of closed femoral fracture
  10. Parasitological examination of imported and indigenous malaria in tegalombo community health center, pacitan disctrict, east jawa province
  11. Review article: how to manage endometrioma by laparoscopy? ablation or excision?
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  13. Review article: the 22 pleiotropic properties of statin and cardiovascular diseases the roles of atorvastatin with its ppeccat-gommesaab effects