Folia Medica Indonesiana
ISSN 0303-7932
Vol. 36 / No. 3 / Published : 2000-07
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Original Article :
Current concept of acute liver failure
Author :
Abstract :
Acute liver failure (ALF) is a clinical syndrome that develops from massive destruction of hepatocyte, and caused severe liver function impairment and hepatic encephalopathy. There are three subclasses of ALF: hyperacute, acute and subacute. The most common cause of ALF is Hepatitis B infection. Hepatic encephalopathy is the major clinical manifestation, which later progresses to multiorgan dysfunction. Histopathologic evaluation shows massive necrosis of liver cells. Treatment is aimed at correcting the complication. Liver support device in preliminary study was well tolerated but this finding needs further clinical trials. Liver biopsy is necessary to determine the time for transplantation, which improves survival rate up to 60-80%. Prognosis depends on the cause, age, and treatment modulation.
Keyword :
Acute Liver Failure, hepatic encephalopathy, hepatitis B, liver transplantation,
References :
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