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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 36 / No. 3 / Published : 2000-07

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Original Article :

Current concept of acute liver failure

Author :

      Abstract :

      Acute liver failure (ALF) is a clinical syndrome that develops from massive destruction of hepatocyte, and caused severe liver function impairment and hepatic encephalopathy. There are three subclasses of ALF: hyperacute, acute and subacute. The most common cause of ALF is Hepatitis B infection. Hepatic encephalopathy is the major clinical manifestation, which later progresses to multiorgan dysfunction. Histopathologic evaluation shows massive necrosis of liver cells. Treatment is aimed at correcting the complication. Liver support device in preliminary study was well tolerated but this finding needs further clinical trials. Liver biopsy is necessary to determine the time for transplantation, which improves survival rate up to 60-80%. Prognosis depends on the cause, age, and treatment modulation.

      Keyword :

      Acute Liver Failure, hepatic encephalopathy, hepatitis B, liver transplantation,

      References :


        Archive Article

        Cover Media Content

        Volume : 36 / No. : 3 / Pub. : 2000-07
        1. Current Concept Of Acute Liver Failure
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        3. Comparison Of Natrilix Sr 1.5 Mg Effectiveness Vs Amlodipin 5 Mg (“pena “ Study), A Double Blind Randomized Study At Out-patient Clinic Of Nephrology And Hypertension, Dr Soetomo Hospital, Surabaya
        4. Infants Mortality Rate Lbw (with Birthweight Of 2000 Grams Or Less) At Dr Soetomo Hospital In 1999
        5. Management Of Cancer Pain In Dr. Soetomo Hospital, Surabaya
        6. A Case Report Sturge-weber Syndrome, A Rare, Debilitating Syndrome
        7. Typhoid Fever, A Continuing Health Challenge In Pediatrics
        8. Progressiveness Of Hydrocephalus In Babies To Toddlers (age 0 – 36 Months), The Use Of Intraventricular Pressure Dynamics And Cerebrospinal Fluid Creatine Phosphokinase Level As Predictors