Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 4 / Published : 2007-10

Order : 3, and page :204 - 209

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Original Article :

Cytologic examination using swab method to evaluate radiologic outcome in nasopharyngeal carcinoma patients post-radiotherapy

Author :

  1. OE Palandeng*1
  2. Hoetomo*2
  3. Widodo Ario Kentjono*3
  1. Department of Otorhinolaryngology, Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Jl Prof Dr Moestopo 6-8, phone 62-31-5501649, Surabaya 60286, Indonesia

Abstract :

Blind biopsy is still a standard procedure for the evaluation of NPC patients after radiotherapy in Oncology Clinic at ENT Department, Dr Soetomo Hospital. There is a problem in this procedure for patients because blind biopsy method could make bleeding and pain. The swab method was conducted by scraping nasopharyngeal area. This method has minimal injury, bleeding and painless. The result was quicker, cheaper as compared to blind biopsy. Swab method had been reported as having low accuracy as compared to blind biopsy to diagnose NPC. The purpose of this study was to analyze of different results of swab method and blind biopsy in patients of NPC after radiotherapy. The diagnostic test study was done by cross sectional comparative design. The population was NPC patients who had total dose of radiotherapy in Radiotherapy Installation, Dr Soetomo Hospital. The samples were taken by consecutive sampling to incoming patients at Oncology Clinic, ENT Department, Dr. Soetomo Hospital during the period of January to May 2005. There were 40 samples to study. The results of cytology and histopathology of the swab method and the blind biopsy in seven patients had a result of positive swab and positive biopsy. Two patients had a result of positive swab and negative biopsy. Three patients had a result of negative swab and positive biopsy. Twenty-eight patients had a result of negative swab and negative biopsy. Statistical analysis of the results with McNemar's test was p = 1.000. This means that there was no significant difference (p > 0.05) between the results of swab method and blind biopsy. The swab method had the sensitivity of 70%, the specificity of 93.3%, the positive predictive value was 77.8%, the negative predictive value was 90.3%, and the accuracy was 87.5%. The conclusion of this study was that the swab method can be a substitution of blind biopsy to evaluate NPC patients after radiotherapy.

Keyword :

Nasopharyngeal carcinoma, post radiotherapy, swab, blind biopsy,

References :

Chew, CT,(1987) Nasopharynx, in Scott-Brown’s Otolaryngology, 5th edn - : Butterworth

Fletcher, RH, Flecher, SW, Wagner, EH,(1988) Clinical Epidemiology, The Essentials, 2nd edn Baltimore : William & Wilkins

Hussey, DH,(1993) Principles of Radiation Oncology, in BJ Bailey (ed), Head and Neck Surgery-Otolaryngology Philadelphia : JB Lippincott Co.

Archive Article

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Volume : 43 / No. : 4 / Pub. : 2007-10
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