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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

TOC : 9, and page :45 - 52

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Original Article :

Dexamethasone study for prenatal lung maturation on lecithin/sphingomyelin ratio in women at risk of preterm birth

Author :

  1. Renny Nurul Faizah*1
  2. Muhammad Yahya*2
  3. Yulistiani*3
  4. Agus Abadi*4
  1. Mahasiswa Fakultas Farmasi
  2. Pharmacy Unit, Dr. Soetomo Hospital, Surabaya
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Kedokteran

Abstract :

Betamethasone and dexamethasone are antenatal corticosteroids used in RDS (respiratory distress syndrome) reduction, the mostfrequent cause of infant prematurity. RDS is related to pulmonary strucure and function immaturity, which is measured withlecithin/sphyngomyelin (L/S) ratio as gold standard. No studies had been conducted comparing dexamethasone in differentregiments. This study was conducted to analyze lower dexamethasone dose in enhancing fetal pulmonary maturity and to analyzedexamethasone use at a dose of 4 and 6 mg every 12 hours for 2 days for accelerating fetal lung maturation in women at risk ofpreterm birth on L/S ratio. This study, reviewed by the ethics committee of Dr. Soetomo Hospital, Surabaya, conducted from July2013 to January 2014, used longitudinal prospective method involving two groups, dexamethasone 4 mg and 6 mg, administeredintramuscularly twice daily for 2 days with total sample size 34 samples. Amniotic fluid samples were taken from women at risk ofpreterm birth with gestational age 28-34 weeks. Lecithin and shingomyelin levels in amniotic fluid were determined by ELISAmethod to calculate L/S ratio. The mean L/S ratio after dexamethasone dose of 4 mg twice daily for 2 days in women at risk ofpreterm birth were 8.7 with L/S ratio ranged 3.5 to 20.8 and after administration of 6 mg dexamethasone it was 10.96 with L/S ratio4.4 to 23.1. In conclusion, L/S ratio between dose dexamethasone 4 and 6 mg was not different in women with preterm birth riskgiven every 12 hours for 2 days. (FMI 2015;51:45-52)

Keyword :

corticosteroids, dexamethasone at dose of 4 mg and 6 mg, dexamethasone for accelerating fetal lung maturity , preterm labour, fetal lung maturity,


References :

  1. Anaokar S, Garry PJ, Standefer JC , (1978). Enzymic assay for lecithin in amniotic fluid. 25, 103-107 : Clin Chem
  2. Ballard PL and Ballard RA , (1995). Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. 173, 254-262 : Am J Obstet Gynecol


   


Archive Article

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Volume : 51 / No. : 1 / Pub. : 2015-01
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