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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

TOC : 6, and page :106 - 109

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Original Article :

Diagnostic value of st2 in patients with acute myocardial infarction

Author :

  1. Priyanto H*1
  2. Nugraha J*2
  3. Edijanto SP*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Acute Myocardial Infarction (AMI) is a major problem threatening Indonesia and many countries. Each year AMI patients areincreasing. ST2 is a novel cardiac marker for diagnosis and prognosis of acute myocardial infarction. The purpose of this study is toseek the diagnostic value of serum ST2 in patients with AMI. This cross sectional study was conducted in 46 patients with maincomplaint of chest pain at the Emergency Department, Dr. Soetomo Hospital from 20 April to 20 July 2013. Sera were examined forST2, and then the diagnostic value was determined using the clinical criteria of AMI according to the Universal Definition ofMyocardial Infarction (2007) as the gold standard. The results of ST2 serum levels measurement showed a sensitivity of 83% andspecificity of 70% at a cut-off value of ST2 16.64 ng/mL and AUC 0.878, p = 0.000. The concordance examination between usingcTn-T levels and ST2 was 48.1%. A significance correlation was obtained with correlation coefficient r = 0.489, p = 0.001 betweenthe levels of cTn-T and ST2. In result, ST2 serum levels can be used for screening to aid the diagnosis of AMI. There is a weakcorrelation and concordance between cTn-T with ST2. Further research is needed to determine the diagnostic value of ST2 for thedetection of AMI. (FMI 2015;51:106-109)

Keyword :

ST2, cTn-T, AMI,


References :

  1. Brown AM, Wu AH, Clopton P, Robey JL, Hollander JE , (2007). ST2 in emergency department chest pain patients with potential acute coronary syndromes. 50, 153-158 : Ann Emerg Med
  2. Kakkar R, Lee RT , (2008). The IL-33/ST2 pathway: therapeutic target and novel biomarker. 7, 827-840 : Nat Rev Drug Discov


   


Archive Article

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Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation of pharmaceutical care in resolving drug problems in type 2 diabetes mellitus
  2. Comparison of the effect of statin types on the reduction of lipid profile and hs-crp inflammatory marker in diabetics with dyslipidemia
  3. Ciprofloxacin is effective in benign prostatic hyperplasia (bph) patients with urethral catheters
  4. Procalcitonin as biomarker of antibiotic effectivity in communityacquired pneumonia
  5. Effect of fursultiamine supplementation on left ventricular ejection fraction (lvef) in grade iii – iv heart failure patients
  6. Diagnostic value of st2 in patients with acute myocardial infarction
  7. Molecular analysis of rpob gene of mycobacterium tuberculosis in patients with suspected pulmonary tuberculosis in surabaya
  8. Liver function tests of patients with dengue fever, dengue hemorrhagic fever and dengue shock syndrome in tropic and infectious disease ward in the department of internal medicine, dr. soetomo hospital, surabaya
  9. Case report: dengue fever with perimyocarditis
  10. Correlation between heat shock protein (hsp) 70 level and left ventricular dysfunction and its effect on cardiovascular and rehospitalization incidence in patients with acute coronary syndrome
  11. Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats
  12. Acetosal resistance in coronary artery disease between and within type 2 diabetes mellitus patients
  13. Immunochromatography method for rotavirus detection provides good accuracy in diagnosis of rotavirus diarrhea in children