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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 1 / Published : 2014-01

TOC : 10, and page :43 - 47

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Original Article :

Diagnostic values of immature granulocytes, eosinopenia and i/t ratio in detection of early onset neonatal sepsis in neonates with bacterial infection risk

Author :

  1. Eko Bagus*1
  2. Hartono Kahar*2
  3. Puspa Wardhani*3
  1. Resident at the Department of Clinical Pathology Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital Surabaya
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Early Onset Neonatal Sepsis (EONS) is a significant cause of morbidity and mortality in neonates. It is difficult to establish thediagnosis of early onset neonatal sepsis and the gold standard of establishing sepsis is by microbiology method. Thus, usinghematology parameters like immature granulocytes, eosinopenia, and I/T ratio can be used as markers to diagnose sepsis moreefficient, faster and inexpensive. The aim of this study is to evaluate if immature granulocytes, eosinopenia, and I/T ratio could beused as markers to diagnose EONS in neonates with bacterial infection. Blood samples were taken from 35 neonates patients’ veins.The patients admitted to the Neonatal Intensive Care Unit (NICU) of the Dr Soetomo Hospital were 0-6 hours old with a high risk ofbacterial infection and received no antibiotic treatment, this study was cross sectional. Immature granulocytes, eosinopenia and I/Tratio were analyzed separately using automatic analyzer instrument. Whole blood was taken from patients’ umbilical cord forculture. Then, value of immature granulocytes, eosinopenia and I/T ratio were compared to the blood culture results. From 35neonatal samples, IG showed a sensitivity of 38.1 %, specificity 64.3 %, positif predictive values (PPV) 61.5%, and negativepredictive values (NPV) 40.9 %. Eosinopenia showed a sensitivity of 28.6%, specificity 100%, PPV 100% and NPV 48.3%. I/T ratioshowed a sensitivityof 23.8%, specificity 85.7%, PPV 71.4% and NPV 42.7%. IG showed the most sensitivity value and eosinopeniashowed the most specificity value for detection of EONS.

Keyword :

immature granulocytes, eosinopenia, I/T ratio, early onset neonatal sepsis,

References :

  1. Abidi K, Khoudri I, Belayachi J, Madani N, Zekraoui A, Zeggwagh AA, Abouqal R, (2008). Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. - : Crit Care
  2. Ansari-Lari MA, Kickler TS, Borowitz MJ, (2003). Immature granulocyte measurement using the Sysmex XE-2100. Relationship to infection and sepsis. - : Am J Clin Pathol


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Volume : 50 / No. : 1 / Pub. : 2014-01
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