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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 3 / Published : 2005-07

TOC : 9, and page :222 - 229

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Original Article :

Different clinical manifestation of cerebral lupus due to different brain involvement. a report of two cases

Author :

  1. Raihan*1
  2. Rizal Altway*2
  3. Niniek Soemiarso*3
  4. Sjaifullah Noer*4
  5. Ariyanto Harsono*5
  1. Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Hospital Surabaya
  2. Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Hospital Surabaya
  3. Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Hospital Surabaya
  4. Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Hospital Surabaya
  5. Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Hospital Surabaya

Abstract :

Involvement of the nervous system in systemic lupus erythematosus (SLE) is frequent. The most often clinical manifestations include psychosis, mood disorders, seizure, acute confusional states, headache, cranial nerve palsies, ataxia, nystagmus, papilloedema, meningitis, tremor, cortical blindness, and coma. There are no specific laboratory or magnetic resonance imaging findings, making a proper diagnosis often difficult. We report two cases of cerebral lupus in a thirteen-year-old and ten and a half year old girl. The first case presenting with fever, headache, right hemi paresis, aphasia, and somnolence. Neither meningeal signs nor pathologic reflexes were found. CT-scan revealed a white matter infarction, symmetrical on frontal lobe, midline slight shift to the left, but cerebral bleeding was not noted. The diagnosis of SLE of this patient was based on malar rash, oral ulcers, pleuritic pain, neurological disorders, and positive anti-DNA antibody and ANA test. The second patient had been diagnosed lupus nephritis since 5 months ago. She was hospitalized because of dyspnea and behavioral disorder. CT-scan revealed severe brain atrophy. Both patients were treated with methylprednisolon pulse 30 mg/kg/day for three days and followed with oral prednisone 2 mg/kg/day. Both of these patients were discharge on good conditions.

Keyword :

Systemic Lupus Erythematosus, diagnosis, cerebral lupus, brain involvement, prednisolon, prednisone,


References :

  1. Klein-Gitelman MS, Miller ML, (2004). Systemic lupus erythematosus. In: Behrman RE, Kliegman RM, Arvin AM, Eds. Nelson Textbook of Pediatrics, 18th ed. . Philadelphia : WB Saunders Company
  2. Wallace DJ, Hahn BH, (1998). Dubois' lupus erythematosus . Philadelphia : Lippincot Williams & Wilkins


   


Archive Article

Cover Media Content

Volume : 41 / No. : 3 / Pub. : 2005-07
  1. Editorial vol 41 no 3 2005
  2. Opinion: the dramatic avian influenza epidemic and the pig connection
  3. The potency of piperine as antiinflammatory and analgesic in rats and mice
  4. Brain derived neurotrophic factor (bdnf) is a key mediator of learning plasticity
  5. Migraine headache in a child with house dust and mite allergy. a case report
  6. Long versus standard initial steroid therapy for children with idiopathic nephrotic syndrome
  7. Research article: the effect of nursing care approach model (ncam = pakar) on the increase of cd4 cell count for patient with hiv infection
  8. Clinical outcome of asthma with house dust immunotherapy in children
  9. Different clinical manifestation of cerebral lupus due to different brain involvement. a report of two cases
  10. A comparative test of eyedrops timolol 0.5% and betaxolol 0.5% in the reduction of intraocular pressure in primary open-angle glaucoma in dr soetomo hospital, surabaya
  11. Efficacy of fine needle biopsy in the diagnosis of tuberculous cervical lymphadenitis
  12. Molecular and immunological aspects of anemia in malaria
  13. Review article and clinical experience: insulin glargine combined with oral agent in t2dm (clinical uses of formulas: 1/3, 5-5, 2-2, 1-1, and 1-2)