UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 1 / Published : 2010-01

Order : 3, and page :15 - 23

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Original Article :

Effect of probiotic administration on the levels of fecal secretory immunoglobulin a in premature infants

Author :

  1. Lucia Pudyastuti Retnaningtyas*1
  2. Risa Etika*2
  3. Subijanto Marto Sudarmo*3
  1. Department of Child Health, Faculty of Medicine, Airlangga University, Dr Soetomo General Hospital, Surabaya
  2. Department of Child Health, Faculty of Medicine, Airlangga University, Dr Soetomo General Hospital, Surabaya
  3. Department of Child Health, Faculty of Medicine, Airlangga University, Dr Soetomo General Hospital, Surabaya

Abstract :

Secretory immunoglobulin A (sIgA) plays an important role in the defence of the gastrointestinal tract. The level of fecal sIgA is associated with increased neutralization and clearance of viruses. Preterm infant whose delay of intestinal colonization may benefit from strategies to support maturation of humoral immunity and endogenous production of sIgA by early colonization with probiotic. The objective of this study was to evaluate the effect of probiotic on the fecal sIgA level in newborn preterm infants. A randomized double-blind placebo control study of newborn preterm infants (30-36 weeks of gestational age) who were spontaneous delivered and had no asphyxia was conducted in NICU Soetomo Hospital-Surabaya November-December 2006. Both groups were breast fed. Group probiotic was given multistrain probiotic containing 107 cfu of Lactobacillus acidophilus, Bifidobacterium longum, and Streptococcus faecium once daily for 14 days since 2nd day of age. The control group was given placebo. Fecal sIgA was determined by an enzyme-linked immunosorbent assay before and after intervention. Subject/s who got Respiratory Distress Syndrome or sepsis during study was dropped out. Statistical analysis used in this study were Chi-square, Paired t - test, Independent sample t - test, Mann-Whitney, Wilcoxon Signed Ranks test, and Multivariate analysis of variance (α = 0.05). Forty seven neonates were enrolled, 7 of them were drop out (2 with RDS, 5 with sepsis). Forty analyzed neonates were divided in probiotic (n=20) and placebo group (n=20). There was no significant difference about basic characteristics between the groups. At first examination, median of fecal sIgA level did not differ significantly between two groups (p=0.512), 0.164 and 0.174 mg/g feces in probiotic and placebo group respectively. There was higher increment of fecal sIgA level in probiotic than placebo group (1.735 vs 1.449 mg/g feces, p=0.003). In conclusion, preterm infants may benefit from probiotic because of the observed clear tendency to increase fecal sIgA secretion.

Keyword :

preterm infant, probiotic, fecal sIgA,


References :

Gomella, TC,(1999) Infectious disease, in TC Gomella (ed.), Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 4th edn New York : McGraw-Hill Co.

Gottof, SP,(2004) Infections of the neonatal infant, in RE Behrman, RM Kliegman & HB Jenson (eds), Nelson Textbook of Pediatrics, 17th edn Philadelphia : WB Saunders

Stoll, BJ & Kliegman, RM,(2004) Infections of the neonatal infants, in RE Behrman, RM Kliegman & HB Jenson (eds), Nelson Textbook of Pediatrics, 17th edn Philadelphia : WB Saunders





Archive Article

Cover Media Content

Volume : 46 / No. : 1 / Pub. : 2010-01
  1. Comparison Between The Results Of Acid Fast Bacilli Obtained From Spontaneous Sputum With Sputum Induction By Saline 0.9 % And By Salbutamol Nebules In The Diagnosis Of Sputum Smear Negative Pulmonary Tuberculosis
  2. Role Of Free Radicals In Children With Malnutrition
  3. Effect Of Probiotic Administration On The Levels Of Fecal Secretory Immunoglobulin A In Premature Infants
  4. The Implementation Of Hidden Markov Model For Exon Prediction On Dna-gene Plasmodium Falciparum
  5. Correlation Between Cox-2 Expression With Histopathological Grading In Astrocytoma
  6. Effect Of Low Lead Exposure On Gestational Age, Birth Weight And Premature Rupture Of The Membrane
  7. Diagnostic Accuracy Of Pre-operative Fine Needle Aspiration Biopsy In Ameloblastoma
  8. Chemical Analysis Of Loranthaceae Daendropthoe Sp. By Thin Layer Chromatography
  9. Molecular Characterization Of Mexb Gene Fragment In Bandung Isolate Multiresistant Pseudomonas Aeruginosa
  10. Gracilis Muscle Transposition For Traumatic Anal Incontinence A Case Report
  11. Review Article: Management Of Polycystic Ovary Syndrome In Adolescent
  12. The Clinical Features Of Transient Elastography (fibroscan) Examination Among Liver Diseases Patients At Gastroenterohepatology Division Of Dr. Soetomo Hospital, Surabaya