UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 4 / Published : 2013-10

Order : 4, and page :220 - 225

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Original Article :

Effect of red yeast rice (monascus purpureus) extract to the trombopoietin level in dengue infected patients

Author :

  1. Muhammad Noor Diansyah*1
  2. Suharto*2
  3. Erwin Astha Triyono*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Thrombocytopenia is the key component and important parameter in dengue infection from the potency of bleeding and lifethreatening condition. Angkak (red yeast rice) a fermented product of rice and red yeast (Monascus purpureus), has been used inIndonesia to increase platelet count in dengue infection. Pre-clinical research has shown that Monascus purpureus extract canincrease platelet count significantly. However the mechanism has not been understood clearly. It has been suggested that themechanisms are due to anti-inflammatory effect or the stimulation of thrombopoiesis. Research design used single blind randomizedcontrolled trial. The subjects of this research were patients with dengue infection, hospitalized in Tropical-Infectious Disease Ward,RSUD Dr. Soetomo Surabaya. The total samples were 30 patients who divided into trial group (n=15) and control group (n=15).Trial group received standard therapy for dengue infection and Monascus purpureus extract capsule 3 times 1 capsule daily for 48hour. Control group received standard therapy for dengue infection. TPO levels was measured before and 48 hour after treatment.The comparative analysis on both groups shows that between 15 patients in trial group and 15 patients in control group, there aredecrease of TPO level (median value) from 90 pg/mL to 26,6 pg/mL, and from 130 pg/mL to 66,8 pg/mL respectively. Trial group hasgreater decrease of TPO level (63,4 pg/ml) than control group (63,2 pg/ml) but statistically not significant (p = 0,916).(FMI2013;49:220-225)

Keyword :

Monascus purpureus, Thrombopoietin, Dengue Infection,


References :

Arunachalam C and Narmadhapriya D,(2011) Monascus fermented rice and its beneficial aspects: a new review - : Asian Journal of Pharmaceutical and Clinical Research

Cardier JE, Balogh V, Perez-Silva C, Romano E, Rivas B, Bosch N, Rothman AL,(2006) Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease - : Cytokine





Archive Article

Cover Media Content

Volume : 49 / No. : 4 / Pub. : 2013-10
  1. Relationship Between N-terminal Pro-brain Natriuretic Peptide (nt-probnp) Level And Protein St2 Level In Acute Coronary Syndrome Patient
  2. The Effect Of Lime Peel Extract (citrus Aurantifolia) To Total Blood Cholesterol Levels Of Mice (mus Musculus) That Given The High Cholesterol Diet
  3. Monitoring Of Potassium Level On The Heart Failure Patients Using Captopril And Furosemide
  4. Effect Of Red Yeast Rice (monascus Purpureus) Extract To The Trombopoietin Level In Dengue Infected Patients
  5. Amaranthus Tricolor Linn Preserves The Thickness Of Seminiferous Tubules In Mice (mus Musculus) Induced By Lead Acetate
  6. Effect Of Low Molecular Weight Topical Hyaluronate On White Rat Superficial Wounds Epithelization Treated With Freeze-dried Amnion Membrane
  7. Profile Of Chest And Abdomen Ultrasound On Patients With Dengue Virus Infection In Dr. Soetomo Hospital Surabaya Between February-april 2012
  8. The Prevalence Of Extended Spectrum Beta-lactamase (esbl) In Third Generation Cephalosporin Usage Among Sepsis Patients In The Department Of Internal Medicine Rsud Dr. Soetomo Surabaya
  9. Case Report: Management Of Peptic Ulcer Infection Due To Helicobacter Pylori Infection And Abscess Liver Bowel Perforation
  10. Difference Of Pain Intensity In Tension Type Headache Patients Focusing On The Personality
  11. Hearing Disorder In Multidrug-resistant Tuberculosispatients Atthe Outpatients Unit, Pulmonary Department, Dr. Soetomo Hospital Surabaya
  12. The Difference Of Heart Rate Recovery Among Obese Subjects With And Without Metabolic Syndrome
  13. Dysfunction Of Cochlear And Retrocochlear With Tinnitus In Normal Hearing