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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

TOC : 11, and page :132 - 136

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Original Article :

Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats

Author :

  1. Arief Widya Prasetya*1
  2. Yhenti Widjayanti*2
  1. Diploma Program of Nursing, Catholic Health Science Academy, St. Vincentius a Paulo, Surabaya
  2. Diploma Program of Nursing, Catholic Health Science Academy, St. Vincentius a Paulo, Surabaya

Abstract :

Menopausal period is a hipoestrogen condition. In menopausal periode, some woman get vaginal atrophy because of decreasingestrogen level. It can cause a decline of vagina elastisity. Tomatoe is known as rich of lignan phytoestrogen. Phytoestrogen canincrease estradiol level on blood. However the effect of tomato juice toward the elastisity of vaginal wall of ovariectomized rattus isstill unknown. The purpose of this research was to study the effect of tomato juice (Lycopersicum commune) toward elastisity of thevaginal wall of ovariectomized rattus. This study was a laboratory experiment using Post test Only One Control Group Design. Thisstudy used 24 female-ovariectomized Rattus norvegicus Wistar strain randomly divided into 4 groups, one control group (K) andthree treatment groups three defference dosage of tomato juice that is 110 mg/kgBW/day (P1), 220 mg/kgBW/day (P2) and 330mg/kgBW/day (P3) for 28 days. The results showed that there was an increaseof collagen synthesis in vagina wall of ovariectomizedrattus. The Control group showed the lowest level of estradiol = 67.43% + 2.82., while the highest result was found on group P393.29% ± + 2.63. One-way ANOVA test showed a significant difference between control group and all treatment groups. Hence thestudy shows that the application of tomato juice indeed increase the elastisity of the vaginal wall during menopause. (FMI2015;51:132-136)

Keyword :

menopause, tomato juice, elastisity of the vaginal wall,

References :

  1. Bachmann GA and Nevadunsky NS , (2000). Diagnosis and treatment of atrophic vaginitis. 61, 3090-3096 : American Family Physician
  2. Brincat MP, Baron YM, Galea R , (2005). Estrogens and the skin. 8, 110–123 : Climacteric


Archive Article

Cover Media Content

Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation of pharmaceutical care in resolving drug problems in type 2 diabetes mellitus
  2. Comparison of the effect of statin types on the reduction of lipid profile and hs-crp inflammatory marker in diabetics with dyslipidemia
  3. Ciprofloxacin is effective in benign prostatic hyperplasia (bph) patients with urethral catheters
  4. Procalcitonin as biomarker of antibiotic effectivity in communityacquired pneumonia
  5. Effect of fursultiamine supplementation on left ventricular ejection fraction (lvef) in grade iii – iv heart failure patients
  6. Diagnostic value of st2 in patients with acute myocardial infarction
  7. Molecular analysis of rpob gene of mycobacterium tuberculosis in patients with suspected pulmonary tuberculosis in surabaya
  8. Liver function tests of patients with dengue fever, dengue hemorrhagic fever and dengue shock syndrome in tropic and infectious disease ward in the department of internal medicine, dr. soetomo hospital, surabaya
  9. Case report: dengue fever with perimyocarditis
  10. Correlation between heat shock protein (hsp) 70 level and left ventricular dysfunction and its effect on cardiovascular and rehospitalization incidence in patients with acute coronary syndrome
  11. Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats
  12. Acetosal resistance in coronary artery disease between and within type 2 diabetes mellitus patients
  13. Immunochromatography method for rotavirus detection provides good accuracy in diagnosis of rotavirus diarrhea in children