Folia Medica Indonesiana
ISSN 0303-7932
Vol. 51 / No. 2 / Published : 2015-04
Order : 11, and page :132 - 136
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Original Article :
Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats
Author :
- Arief Widya Prasetya*1
- Yhenti Widjayanti*2
- Diploma Program of Nursing, Catholic Health Science Academy, St. Vincentius a Paulo, Surabaya
- Diploma Program of Nursing, Catholic Health Science Academy, St. Vincentius a Paulo, Surabaya
Abstract :
Menopausal period is a hipoestrogen condition. In menopausal periode, some woman get vaginal atrophy because of decreasingestrogen level. It can cause a decline of vagina elastisity. Tomatoe is known as rich of lignan phytoestrogen. Phytoestrogen canincrease estradiol level on blood. However the effect of tomato juice toward the elastisity of vaginal wall of ovariectomized rattus isstill unknown. The purpose of this research was to study the effect of tomato juice (Lycopersicum commune) toward elastisity of thevaginal wall of ovariectomized rattus. This study was a laboratory experiment using Post test Only One Control Group Design. Thisstudy used 24 female-ovariectomized Rattus norvegicus Wistar strain randomly divided into 4 groups, one control group (K) andthree treatment groups three defference dosage of tomato juice that is 110 mg/kgBW/day (P1), 220 mg/kgBW/day (P2) and 330mg/kgBW/day (P3) for 28 days. The results showed that there was an increaseof collagen synthesis in vagina wall of ovariectomizedrattus. The Control group showed the lowest level of estradiol = 67.43% + 2.82., while the highest result was found on group P393.29% ± + 2.63. One-way ANOVA test showed a significant difference between control group and all treatment groups. Hence thestudy shows that the application of tomato juice indeed increase the elastisity of the vaginal wall during menopause. (FMI2015;51:132-136)
Keyword :
menopause, tomato juice, elastisity of the vaginal wall,
References :
Bachmann GA and Nevadunsky NS ,(2000) Diagnosis and treatment of atrophic vaginitis 61, 3090-3096 : American Family Physician
Brincat MP, Baron YM, Galea R ,(2005) Estrogens and the skin 8, 110–123 : Climacteric
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