Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 1 / Published : 2011-01

Order : 4, and page :15 - 19

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Original Article :

Effectiveness omeprazole and lansoprazole in dyspepsia patient with nepean dyspepsia index

Author :

  1. Anisyah Achmad*1
  1. Department of Clinical Pharmacy, Major of Pharmacy, University of Jenderal Soedirman , Dr. Soeparno Hospital

Abstract :

In patients with dyspepsia, a common initial management strategy in primary care is to prescribe a course of empiric antisecretory therapy. Lansoprazole and omeprazole as antisecretory agents have been proven effective for treatment of dyspepsia. This study was aimed is to compare the effect of Omeprazole (1 x 20 mg) and Lansoprazole (1x 30 mg) to ambulatory dyspepsia patient by using questionnaire quality of life Nepean Dyspepsia Index (NDI) in RSU. Prof. Dr. Margono Soekardjo Purwokerto Juny until August 2009. Dyspepsia Index (NDI) which was translated and validated in Indonesian language. A number of 79 subjects with a clinical diagnosis of dyspepsia according to the inclusion criteria were recruited and randomized to receive Omeprazole 20 mg once daily and Lansoprazole 30 mg once daily. Symptoms of dyspepsia were evaluated by using NDII at baseline one week after treatment. The outcomes of Omeprazole and Lansoprazole were evaluated by comparing improved NDII score in 5 domains (tension, activities, eating/drinking, knowledge/control and work/study). After one week treatment, the NDII dyspepsia patients score in Lansoprazole treated group was significantly different from that in Omeprazole treated group in domains activities and eating/drinking. In conclusion, the effect of Lansoprazole was better than Omeprazole when it was given as empirical treatment for dyspepsia patients.

Keyword :

Dyspepsia, NDI, Lansoprazole, Omeprazole,

References :

Arinton IG, Pugud Samudro, Eman Sutrisna & Wibawa IDN,(2006) Randomized Clinical Trial of Omeprazole and Ranitidine using Indonesian Translated nepean Dyspepsia Index - : J Penyakit Dalam

Brennan M.R. Spiegel, Nimish B.Vakil & Joshua J Ofman S ,(2002) Dyspepsia Management in Primary Care: A Decision Analysis of Competing Strategies - : Gastroenterology

McDonough P & Walters V ,(2001) Gender and Health: Reassessing Patterns and Explanations - : Soc Sci Med

Archive Article

Cover Media Content

Volume : 47 / No. : 1 / Pub. : 2011-01
  1. Evaluation Of Burn Unit Gbpt Performance From 2006-2008. A Retrospective Study
  2. Sex Determinant Of Human Hair With Dna Analysis Method Using Polymerase Chain Reaction (pcr)
  3. Protein Kinase C: After The Combination Of Metformin And Hyperbaric Oxygen Therapy In Type 2 Diabetes Patients
  4. Effectiveness Omeprazole And Lansoprazole In Dyspepsia Patient With Nepean Dyspepsia Index
  5. Decrease Of Cross Shift And Cross Week Blood Cholinesterase Activity In Pesticide Sprayer Of Onion Farmers
  6. Identification Of Mycobacterium Tuberculosis Adhesion Protein In Sputum Of Tuberculous Patients
  7. Correlation Of Histopathological Skin Biopsies With Clinical Diagnosis In Leprosy
  8. Review Article: Reducing Maternal Mortality Rate (mmr) And Infant Mortality Rate (imr): Non Institutional Delivery Or Institutional Delivery?
  9. Maternal Risk Factors Of Premature Delivery In Dr Soetomo Hospital
  10. Citric Acid Reduces The Content Of Pb And Cd Of Kupang Beras (corbula Faba)
  11. Difficulty In Achieving Hemodialysis Adequacy In Hemodialysis Unit, Dr. Soetomo Hospital, Surabaya, Indonesia
  12. Acute Toxicity Test Of Bark And Stem Ethanol Extract Of Sopang (caesalpinia Sappan Linn) By Brine Shrimp Lethality Test
  13. Penile Length Of Newborn Infants In Dr. Soetomo Hospital Surabaya. A Preliminary Study