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Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

TOC : 11, and page :281 - 284

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Original Article :

Encephalopathy and neuroendocrine disorder in septic shock

Author :

  1. OS Hartanto*1
  1. Medical Faculty Sebelas Maret University Surakarta, Indonesia

Abstract :

Infection by pathogenic microorganisms triggers an acute phase response which manifests itself with fever, neuroendocrine changes and behavioral changes. Sepsis induced early impairment of neuronal metabolism and activity. Septic encephalopathy is a severe brain dysfunction caused by systemic inflammation in the absence of direct brain infection. Sepsis enhanced the transcription of several pro- and anti-inflammatory cytokines and chemokines including TNF-a, IL-1? and TGF-? in the cerebrum. Activated microglia during sepsis could play a role in behavioral changes associated with systemic infection. Changes in cerebral blood flow, release of inflammatory molecules and metabolic alterations contribute to neuronal dysfunction and cell death.

Keyword :

encephalopathy, neuroendocrine , Sepsis,


References :

  1. Guntur, HA, (2008). SIRS, SEPSIS dan SYOK SEPTIK (Imunologi, Diagnosis dan Penatalaksanaan) . Surakarta : Sebelas Maret University Press
  2. Aberdein, J and Singer, M, (2006). Clinical review: A systematic review of corticosteroid use in infections . - : Critical Care
  3. Annane, D and Caillon, DM, (2003). Corticosteroid in sepsis : From bench to bedside . - : Shock


   


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