UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 11, and page :281 - 284

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Original Article :

Encephalopathy and neuroendocrine disorder in septic shock

Author :

  1. OS Hartanto*1
  1. Medical Faculty Sebelas Maret University Surakarta, Indonesia

Abstract :

Infection by pathogenic microorganisms triggers an acute phase response which manifests itself with fever, neuroendocrine changes and behavioral changes. Sepsis induced early impairment of neuronal metabolism and activity. Septic encephalopathy is a severe brain dysfunction caused by systemic inflammation in the absence of direct brain infection. Sepsis enhanced the transcription of several pro- and anti-inflammatory cytokines and chemokines including TNF-a, IL-1? and TGF-? in the cerebrum. Activated microglia during sepsis could play a role in behavioral changes associated with systemic infection. Changes in cerebral blood flow, release of inflammatory molecules and metabolic alterations contribute to neuronal dysfunction and cell death.

Keyword :

encephalopathy, neuroendocrine , Sepsis,


References :

Guntur, HA,(2008) SIRS, SEPSIS dan SYOK SEPTIK (Imunologi, Diagnosis dan Penatalaksanaan) Surakarta : Sebelas Maret University Press

Aberdein, J and Singer, M,(2006) Clinical review: A systematic review of corticosteroid use in infections - : Critical Care

Annane, D and Caillon, DM,(2003) Corticosteroid in sepsis : From bench to bedside - : Shock





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection
  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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