UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 4 / Published : 2014-10

Order : 5, and page :226 - 233

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Original Article :

Evaluation of renal function in cervix cancer patients by dose cisplatin 75 mg/m2 with nacl-manitol hydration

Author :

  1. Intan Sari Dewi*1
  2. Yulistiani*2
  3. Heru Santoso*3
  4. Muhammad Yahya*4
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran
  4. Clinical Pharmacist, Departement of Pharmacy, Dr. Soetomo Hospital Surabaya

Abstract :

Cisplatin is one of platinum cytostatic drug for the medication of solid cancers, one of which is cervical cancer. Adverse event thatresulted during drug treatment was acute or chronic nephrotoxicity. A cross sectional, prospective, observational study wasconducted to evaluate the effect of NaCl-Mannitol hydration on urine production and renal function of cervical cancer patientsreceiving cisplatin 75mg/m2. Inclusion criteria were 21 pastients eClCr Cockroft Gault > 60 ml/min of any cycle, receiving 1 L ofNaCl hydration pre chemoteraphy and 1 L of NaCl plus 30 g Mannitol, 20 mEq KCl, and 1 g MgSO4 for post chemoteraphy. Dataobtained were BUN, SrCr, albumin and eClCr calculation (MDRD and Cockroft Gault), each was measured pre and day six posttreatment. Urine production was measured before chemotherapy and 3 and 12 hours post chemoteraphy hydration. Urine productionof total 21 inpatients had reached > 100 mL/hour at 3rd hour post chemotherapy. There were 8 patients (39%) who experiencedacute nephrotoxicity characterized by an increase of serum creatinine by 1.5 times from the baseline. (FMI 2014;50:226-233)

Keyword :

Cisplatin, hydration, renal impairment, serum creatinine, eClCr,


References :

Arany I, Safirstein RL,(2003) Cisplatin nephrotoxicity 23, 460–464 : Seminars in Nephrology

Miller RP, Tadagavadi RK, Ramesh G, Reeves WB ,(2010) Mechanisms of cisplatin nephrotoxicity 2, 2490-2518 : Toxins (Basel)





Archive Article

Cover Media Content

Volume : 50 / No. : 4 / Pub. : 2014-10
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  2. The Profile Of Genetic Mutation Of The Gyrb Gene On Clinical Isolation Of Acinetobacter Baumannii Resistant To Ciprofloxacin
  3. Relationship Between Platelet Aggregation And Hs-crp In Patients With Pci Receiving Clopidogrel And Aspirin
  4. Correlation Between Preprocedural Hscrp Level And Ck-mb Ratio Pre And Post Percutaneous Coronary Intervention As A Marker Of Preprocedural Myocardial Injury
  5. Evaluation Of Renal Function In Cervix Cancer Patients By Dose Cisplatin 75 Mg/m2 With Nacl-manitol Hydration
  6. Comparison Of Functional Improvement Scale (nihss) Degree Between Acute Intracerebral Hemorrhage Stroke Patients Receiving Standard Treatment And Those Receiving Standard Treatment Plus Celecoxib
  7. Effectiveness Of Kinesio Taping Compared With Short Wave Diathermy On Pain Perception And Functional Status In Knee Osteoarthritis Patients
  8. Cryptosporidium Action In Fecal And Sputum Samples From Patients With Hiv/aids
  9. Percutaneous Transluminal Angioplasty In Patients With Critical Limb Ischemia
  10. Analysis Of Antibiotic Usage In Patients With Bacteremia In The Icu Unit Of Dr. Soetomo Hospital Surabaya
  11. Analysis Of Blood Sample Lysis Rate On Hemoglobin Examination Results Using Rayto Rt. 7600 Auto Hematology Analyzer
  12. Carotid Artery Stenting In A Patient With Transient Ischemic Attack
  13. Risk Factors Of Low Birth Weight (lbw) Incidence. A Case Control Study

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