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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

TOC : 6, and page :255 - 258

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Original Article :

Exploration in the use of medicinal plant acanthus ilicifolius l in the treatment of endothelial dysfunction

Author :

  1. I Ketut Sudiana *1
  2. Elyana Asnar*2
  3. Sunarko Setyawan*3
  4. Heru Kusbianto*4
  1. Airlangga University Faculty of Nursing
  2. Airlangga University Faculty of Medicine
  3. Airlangga University Faculty of Medicine
  4. Airlangga University Faculty of Medicine

Abstract :

Endothelial dysfunction is an important factor of growth and development in atherosclerotic process. Atherosclerosis is a vascular disease. Indicators applied to determine endothelial dysfunction are, for example, VCAM and TNF-a. In this articlethe regulation of vascular defect or inflammation/abscess case in rural area used Acanthus ilicifolius L fruit. However, the extract effect of Acanthus ilicifolius L fruit to suppress of VCAM and TNF-a expression remains unclear. The authors performed animal trial to Rattus novergicus that were divided in three groups. Group one, comprised 5 animals, served as control, group two of five animals were induced with LPS H. pylori 2.5 ug/kg BW intramuscularly, and group three of five animals were induced with LPS H. pylori in the same way and given with the extract of Acanthus ilicifolius L fruit (with a dose of 70 mg/kg BW in 0.5% CMC per-oral/day) for ten days. This experimental research used posttest only control group design. The analysis unit was heart organ. Heart section was made with thickness between 4-6 u. Staining was performed with indirect immunohistochemestry. The results obtained using data analysis (t-test) were as follows : (1) There was significant difference between VCAM and TNF-a group of control with group induced by LPS H. pylori (p < 0.05). (2) There was no significant difference between VCAM and TNF-a in control group with group induced by LPS H. pylori receiving the extract of Acanthus ilicifolius L fruit (p > 0.05). (3) There was significant difference between group of induced with LPS H. pylori with group induced with LPS H.pylori and extracts of Acanthus ilicifolius L fruit (p < 0.05). Thereby, it can be concluded that the extract of Acanthus ilicifolius L fruit can suppress the expression of VCAM and TNF-a. This research should be developed furthermore especially for active agent insulator, and should also be done by clinical test to larger animals before being applied to human.

Keyword :

Atherosclerosis, Inflammation , Mangrove plant (Acanthus ilicifolius L),


References :

  1. Darnell, J, Lodish, H, Baltimore, D, (1990). Molecular Cell Biology, 2nd edn . New York : Scientific American Book
  2. Kalim, H and Handono, K, (2000). Masalah penyakit reumatik di indonesia serta upaya-upaya penanggulangannya . - : Temu Ilmiah Reumatologi
  3. Kanchanapoom, T, Kamel, MS, Kasai, R, Picheansoonthon, C, Hiraga Y, Yamasaki, K, (2000). Lignan glucosides from Acanthus ilicifolius . - : J Phytochemestry


   


Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic variation of g6pd and adaptive phenomena in malarial infection
  2. Molecular analysis of the coding sequence of mage-1 gene from hepatocelular carcinoma patient and testis
  3. Potential value of c-reactive protein as inflammation marker and il-1β, tnf- as pro-inflammatory cytokine on disease activity of rheumatoid arthritis
  4. Cell surface her2/neu oncoprotein expression in breast ductal carcinoma
  5. Difference in the productivity of b-lymphocyte isolated from lymph nodes and that isolated from mice spleen in the production of toxocara cati monoclonal antibody using hybridoma technology
  6. Exploration in the use of medicinal plant acanthus ilicifolius l in the treatment of endothelial dysfunction
  7. Detection of m. tuberculosis and drug sensitivity test from sputum culture of pulmonary tuberculosis patients in dr soetomo general hospital between 2003-2004
  8. The pharmacokenetics of levofloxacin in healthy rabbit treated with antacid
  9. Potency of lactobacillus reuteri on reduced inflammation in septic encephalopathy
  10. Pharmacokinetic parameters determination of a single 500-mg oral dose of levofloxacin in healthy subjects by using blood data
  11. Encephalopathy and neuroendocrine disorder in septic shock
  12. Osteoarthritic pain treatment with electroacupuncture
  13. Review article and clinical experience: astaxanthin – oxidative stress – diabetes mellitus from basics to clinics and from general to specific