Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 2 / Published : 2009-04

Order : 9, and page :130 - 144

Related with : Scholar   Yahoo!   Bing

Original Article :

Expression of p53 oncoprotein in human ductal breast carcinoma (in situ, invasive and metastatic)

Author :

  1. Imam Susilo*1
  1. Department of Anatomic Pathology, Airlangga University School of Medicine, Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

Breast cancer is a malignant tumor mostly disclosed in women. It has heterogeneous biological behavior - so that the knowledge of tumor markers is very important to determine its prognosis and therapy. Up to now, the determination of prognosis and treatment of choice is still based on clinical and morphologic finding although recent studies pointed out that there was tight relationship between carcinoma growth and molecular abnormalities including normal cell gene consisting of proto-oncogene, tumor suppressor gene, programmed cell death and DNA repair gene. Therefore, the description of molecular changes is required - in determining the prognosis and therapy of breast cancer. Molecular pathologic approach may offer a prospective promise even though the genetic mechanism of molecular carcinogenesis in breast cancer is still unclear. In this study, immune pathologic investigation was carried out by using immune histochemical method, with antibody monoclonal against protein p53. Based on multivariate test of Wilks' Lambda method, p53 protein expression was concomitantly different in various tumor diameters of breast cancer (p = 0,000 < α = 0,05). With methode of  Wilks' Lambda method, protein expression  p53 was simultaneously different in various carcinoma cell differentiation of breast cancer (p = 0,000 < α = 0,05) and with Wilks' Lambda method, protein expression  p53 was concomitantly different in various progressiveness of ductal carcinoma growth (p= 0,000 < α= 0,05). Also with Wilks' Lambda method, p53 protein expression was concomitantly different in various grade of ductal carcinoma (p = 0,000 < α = 0,05).      The result designated that there was a significant difference among four breast cancer groups (p= 0,000 < α= 0,05) and  oncoprotein expression  contributed on cellular activity in carcinogenesis of breast cancer.   It showed that malignancy occurred in genetic lesion.

Keyword :

breast cancer, prognosis, molecular pathological role (p53 - protein expression),

References :

Cooper, GM & Hausman, RE,(2004) The Cell, A Molecular Approach, 3rd edn Massachusetts : Sunderland

Cotran, RS, Kumar, V & Collin, T,(1996) Robbins Pathologic Basis of Disease, 6th edn Philadelphia : WB Saunders Co

Gronbaek , H, Flyvbjerg, A, Mellekjaer, L, et al,(2004) Serum insulin- like growth factors, insulin- like growth factor binding proteins, and breast cancer risk in postmenopausal women - : Cancer Epidemiol Biomarkers Prev

Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2009-04
  1. Correlations Between Hip Abductor’s Performance With Hip Bone Mineral Density In Elderly Women
  2. 14.5 Kda Protein Of Plasmodium Falciparum Is A Specific Asexual Stage Antigen Recognized By Pooled Of Mouse Immune Sera
  3. The Expression Of Mitochondrial Heat Shock Protein 10 In Oral Lesions With Hpv Positive
  4. Nosocomial Infection Monitoring Using Urine Catheter
  5. Pattern Of Community Role Development As An Effort To Increase Tuberculosis Patients Coverage With Passive Case Finding
  6. Effectiveness Of Cigarette Butts As An Alternative Material For Forensic Dna Identification With Polymerase Chain Reaction (pcr) In Short Tandem Repeat (str) Loci
  7. Effect Of Friction Technique Massage For Leg After Maximal Exercise On The Removal Rate Of Blood Lactate
  8. Physiological Effects Of Music During Exercise Secretion Of Hormones Cortisol And Endorphins
  9. Expression Of P53 Oncoprotein In Human Ductal Breast Carcinoma (in Situ, Invasive And Metastatic)
  10. Review Article : Congenital Heart Disease. The Holistic Approach, Now And  In The Future In Indonesia
  11. Review Article: Management Of Subclinical Ventricular Dysfunction
  12. Review Article: Exercise And Brain Health In Elderly
  13. Review Article And Clinical Experience: Emerging Multiple Properties Of High Dose Thiamine And B6-b12 Vitamins Therapeutic Possibilities For Diabetic Vascular Complications