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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 3 / Published : 2010-07

TOC : 13, and page :233 - 236

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Original Article :

Expression of topoisomerase iiα and cyclin d1 proteins in various degrees of breast ductal carcinoma

Author :

  1. Imam Susilo*1
  1. Department of Anatomic Pathology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Breast cancer is the most common malignancy and a major cause of death in women worldwide. Protooncogene cyclin D1 is to control the cell cycle and topoisomerase IIa has an important role in DNA replication as well as a specific target of some chemotherapeutic agents. Amplification of topoisomerase IIa is regarded to a poor prognosis, but it is a good predictor response to cytotoxic chemotherapy. The relationship between the histopathological degree of invasive ductal breast carcinoma and the expression of topoisomerase IIa and cyclin D1 is still unclear. This study aimed to determine the relationship between topoisomerase IIa and cyclin D1 with the histopathological degree of invasive ductal breast carcinoma. In this retrospective and cross-sectional study, researchers obtained the degree of histopathological data from medical records. Immunohistochemical examination of cyclin D1 and topoisomerase IIa was performed on paraffin block specimens from 35 patients with invasive ductal breast carcinoma at the Department of Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital from January to December 2009. Based on the histopathological degree, found 5 cases (14.3%) degree of good, 12 cases (34.3%) moderate and 18 cases (51.4%) degrees bad. The expression of topoisomerase IIa were 62.9% (22 cases) and cyclin D1were were 54.3% (19 cases). It is known that the expression of topoisomerase IIa and cyclin D1 was not related to the histopathological degree of invasive ductal breast carcinoma (p = 0.091). As a conclusion, topoisomerase IIa and cyclin D1 does not play a role in differentiation, proliferation and carcinogenesis of tumor cells in invasive ductal breast carcinoma.

Keyword :

invasive ductal breast carcinoma, topoisomerase II, cyclin D1, histopathological degree,

References :

  1. Kusumowardojo, Panuwun T et al., (2004). Beberapa Aspek Sitologi & Histologi Kanker Payudara . Surabaya : Indonesian Issue on Breast Cancer I
  2. Hellemans P, van Dam AP, Geyskens M, van Oosterom TA et al., (1995). Immunohistochemical study of topoisomerase IIexpression in primary ductal carcinoma of the breast. - : J Clin Pathol
  3. Holley S, Parkers G, Matthias C, Bockmuhl U, Jahnke V, Ledder K, Strange CR, Fryer AA, Hobban PR, (2001). Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck . - : American Journal of Pathology


Archive Article

Cover Media Content

Volume : 46 / No. : 3 / Pub. : 2010-07
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  13. Expression of topoisomerase iiα and cyclin d1 proteins in various degrees of breast ductal carcinoma