Catalog :




Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 1 / Published : 2006-01

TOC : 8, and page :47 - 53

Related with : Scholar   Yahoo!   Bing

Original Article :

Fev1-reversibility in house-dust immunotherapy compared with inhaled corticosteroid in the treatment of childhood asthma

Author :

  1. Arijanto Harsono*1
  2. Lisa A Subrata*2
  3. Anang Endaryanto*3
  1. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  2. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  3. Division of Allergy and Immunology, Department of Child Health, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

Asthma is a chronic inflammatory disease of the airway. Corticosteroid is the drug of choice to control the inflammation, and prevent the development of airway hyper responsiveness and later airway remodeling. House dust immunotherapy has been shown to be effective in patients with asthma, and also in those who do not respond well to standard drug therapy. Whether immunotherapy is as effective as inhaled corticosteroid need to be studied. The objective of this study is to investigate the ability of house dust immunotherapy to improve clinical index in children with asthma, and to compare its efficacy with inhaled corticosteroid. We evaluated the beneficial effect of house dust immunotherapy in 24 asthmatic children based on the value of FEV1 reversibility before and after treatment, and also compared its efficacy to the inhaled corticosteroid. All the patients were sensitive to house dust allergen. Twenty-four children (group I) treated with house-dust immunotherapy subcutaneously, once a week for 14 weeks, and group II treated with inhaled budesonide 100-200 μg once daily. The result of Wilcoxon Signed Rank Test showed there was a significant improvement between FEV1 reversibility test before and after house-dust immunotherapy (p=0.0001). Analysis with t-test also revealed that the efficacy of house dust immunotherapy did not differ from inhaled budesonide (p=0.872). In conclusion house dust immunotherapy has been shown to be as effective as inhaled corticosteroid in improving clinical outcome in the term of FEV1-reversibility in the treatment of childhood asthma.

Keyword :

Childhood asthma, house dust immunotherapy, inhaled corticosteroid, FEV1 reversibility,


References :

  1. IT Abba, (2003). Allergy desensitization. New York : Marcel Dekker
  2. CA Akdis, (1998). Role of interleukin 10 in specific immunotherapy. no info : J Clin Invest
  3. T Blesken, (1998). Role of interleukin 10 in specific immunotherapy. no info : J Clin Invest
  4. M Akdis, (1998). Role of interleukin 10 in specific immunotherapy. no info : J Clin Invest
  5. P Bradding, (1995). Mast cells and basophiles: their role in initiating and maintaining inflammatory responses. London : Academic Press
  6. AF Walls, (1995). Mast cells and basophiles: their role in initiating and maintaining inflammatory responses. London : Academic Press
  7. MK Church, (1995). Mast cells and basophiles: their role in initiating and maintaining inflammatory responses. London : Academic Press
  8. G Brusselle, (2004). Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice. no info : Am J Respir Cell Mol Biol
  9. J Kips, (2004). Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice. no info : Am J Respir Cell Mol Biol
  10. G Joos, (2004). Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice. no info : Am J Respir Cell Mol Biol
  11. H Bluethmann, (2004). Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice. no info : Am J Respir Cell Mol Biol
  12. R Pauwels, (2004). Allergen induced airway inflammation and bronchial responsiveness in wild type and interleukin-4-de.cient mice. no info : Am J Respir Cell Mol Biol
  13. SG Cohen, (1999). Allergen immunotherapy in historical perspective. New York : Marcel Decker
  14. R Evans, (1999). Allergen immunotherapy in historical perspective. New York : Marcel Decker
  15. PS Creticos, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  16. TE Van Metre, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  17. MR Mardiney, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  18. GL Rosenberg, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  19. PS Norman, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  20. NF Atkinson, (1984). Dose-response of IgE and IgG antibodies during ragweed immunotherapy. no info : J Allergy Clin Immunol
  21. SR Durham, (1996). Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T-lymphocytes and eosinophils in the nasal mucosa and increases the numbers of cells expressing mRNA for interferon-gamma. no info : J Allergy Clin Immunol
  22. J Freeman, (1994). Vaccination against Hay fever: report of results during the first three years. no info : Lancet
  23. AJ Frew, (2003). Immunotherapy of Allergic Disease. no info : J Allergy Clin Immunol
  24. SH Gavett, (2003). Depletion of murine CD41 T lymphocytes prevents antigen-induced airway hyper reactivity and pulmonary eosinophilia. no info : Am J Respir Cell Mol Biol
  25. X Chen, (2003). Depletion of murine CD41 T lymphocytes prevents antigen-induced airway hyper reactivity and pulmonary eosinophilia. no info : Am J Respir Cell Mol Biol
  26. F Finkelman, (2003). Depletion of murine CD41 T lymphocytes prevents antigen-induced airway hyper reactivity and pulmonary eosinophilia. no info : Am J Respir Cell Mol Biol
  27. M Wills-Karp, (2003). Depletion of murine CD41 T lymphocytes prevents antigen-induced airway hyper reactivity and pulmonary eosinophilia. no info : Am J Respir Cell Mol Biol


   


Archive Article

Cover Media Content

Volume : 42 / No. : 1 / Pub. : 2006-01
  1. Toxoplasma gondii infection elicits the increase of fas expression on the trophoblast associated with the increase of trophoblast apoptosis
  2. Effect of laser at pishu point on amount and function of pancreatic β cells (rattus norvegicus) injected by streptozotocin
  3. The effects of unilateral urethral obstruction on tubular cells apoptosis:an experimental study in rabbits
  4. Antimicrobial activities of andrographolide and propolis against intracellular mycobacterium tuberculosis phagocytosed by monocytes derived macrophages
  5. The 2-methoxyethanol toxicity towards the structures of plasma membrane and mitochondria of the rat’s spermatozoa
  6. Genotyping of extended spectrum Β-lactamase escherichia coli strains from clinical specimens
  7. Multiresistance pattern of extended spectrum β-lactamase (esbl) – escherichia coli and klebsiella pnemoniae strains
  8. Fev1-reversibility in house-dust immunotherapy compared with inhaled corticosteroid in the treatment of childhood asthma
  9. Trachoma in pondok pesantren salafiyah syafiiyah, sukorejo, situbondo, east java. a case study
  10. Review article : depression in post-myocardial infarction patients
  11. Review article and clinical experience: the mets: one of the major threat to human health