Folia Medica Indonesiana
ISSN 0303-7932
Vol. 44 / No. 4 / Published : 2008-10
Order : 1, and page :216 - 223
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Original Article :
Genetic variation of g6pd and adaptive phenomena in malarial infection
Author :
- Indah S Tantular*1
- Department. of Parasitology, Airlangga University School of Medicine
Abstract :
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-chromosome-linked hereditary abnormality with a high degree of clinical, biological and genetic variations. Some people are born with a mutation of the G6PD gene, which, when reacting to certain triggers, such as infection, some drugs like anti-malarials drug or some foods such as fava beans, can cause anemia. But those same people also seem more able to resist the worst effects of malaria. More than 300 G6PD variants have been defined, most common are those variants associated with acute intermittent hemolytic anemia. The geographic distribution of populations with a high gene frequency of deficient variants overlaps closely with the prevalence of malaria, suggesting that G6PD deficiency might be protective against malaria. Evidence for a protective affect of G6PD deficiency against Plasmodium falciparum comes from both epidemiological correlation and in vitro studies. Malaria is a major killer worldwide with high mortality rates among children. Of the four common malarial parasites in humans, P. falciparum is the deadliest. There are hundreds of million cases due to other parasite species: P. vivax, P. malariae and P. ovale. The risk of malaria transmission in endemic countries is increased in rural areas and varies seasonally in many locations.
Keyword :
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, Malaria, G6PD variant, Indonesia,
References :
Beutler, E, Yeh, M, Fairbanks, VF,(1962) The normal human female as a mosaic of X-chromosome activity, Studies using the gene for G6PD deficiency as a marker - : Proc Natl Acad Sci USA
Damanik, SM, Ugrasena, IDG, Harianto, A et al.,(2001) Mass screening of G6PD in Dr Soetomo General Hospital - : Folia Medica Indonesiana
Hirono, A, Ishii, A, Kere, N, Fujii, H et al,(1995) Molecular analysis of glucose-6-phosphate dehydrogenase variants in the Solomon Islands - : Am J Hum Genet
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