Folia Medica Indonesiana
ISSN 0303-7932
Vol. 48 / No. 4 / Published : 2012-10
Order : 6, and page :174 - 179
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Original Article :
Guava (psidium guajava l.) juice is effective in lowering blood glucose level in mice (mus musculus)
Author :
- Vini Victoria*1
- Sri Purwaningsih*2
- Suhartati*3
- Mahasiswa Fakultas Kedokteran
- Dosen Fakultas Kedokteran
- Dosen Fakultas Kedokteran
Abstract :
Southeast Asia, including Indonesia, has a high carbohydrate diet, which will lead to a high blood glucose concentration. Continuous high blood glucose can lead to diabetes mellitus (DM), which often caused by genetic and environment. Nowadays, DM therapy covers physical exercise, diet planning, and medicine consumption. Available medicines right now have quite a lot side effect in long term usage. Therefore, we studied an alternate therapy of DM using guava fruit juice. Flavonoids (apigenin, tannin, myricetin, quercetin) in guava fruit were estimated to reduce blood glucose level. The objective of this study was to determine blood glucose-reducing effect of guava juice (Psidium guajava L.) in mice (Mus musculus) using Glucose Tolerance Test (GTT). The experiment was done at Pharmacology Laboratory, Medical Faculty. Airlangga University using mice (Mus musculus), which were divided into 5 groups, each consisting of 7 mice. Measurement of blood glucose level was done by cutting mice’s tail and taking the blood 0, 60, 120, 150 minutes after glucose loading. Results showed that there were significant difference (sig (p) < 0,05) in reduced blood glucose in group given with 25% concentration of guava juice compared to the groups receiving Distilled Water, metformin, 100% guava juice, 50% guava juice groups. In conclusion, guava (Psidium guajava L.) juice in 25% concentration is effective in lowering blood glucose level. (FMI 2012;48:174-179)
Keyword :
Psidium guajava L. , lowering blood glucose, mice, Glucose Tolerance Test,
References :
Badan Penelitian dan Pengembangan Kesehatan,(2008) Riset Kesehatan Dasar 2007 Jakarta : Departemen Kesehatan Republik Indonesia
Gibney MJ, Elia M, Ljunggvist O, Dowsett J,(2005) Clinical Nutrition Oxford : Wiley-Blackwell
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Volume : 48 / No. : 4 / Pub. : 2012-10 |
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