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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 1 / Published : 2007-01

TOC : 4, and page :19 - 22

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Original Article :

Heparin effect on vegf and egfr after deep second and third degree burns in rattus novergicus strain wistar

Author :

  1. Ruby Riana*1
  2. David S Perdanakusuma*2
  1. Department of Plastic Surgery Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Plastic Surgery Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

The objective of this study was to study the effect of heparin on angiogenesis and epithelialization acceleration. The design of this study was experimental. This study used forty eight rats randomly divided into four groups. A group of deep second degree burns and a group of third degree burns were each divided into two groups, experimental and control groups. The experimental group was divided into 2, both treated with 1 ml heparin 100 IU/kg and saline solution injected beneath the burnt skin once daily, in which 1 group received it for 5 days while other up to 10 days. The control group was divided into 2, both treated with 1 ml saline solution injected beneath the burnt skin once daily, in which 1 group received it for 5 days while other up to 10 days. Observation was done at fifth and tenth day. Parameter of angiogenesis was VEGF count. Parameter of epithelialization acceleration was EGFR count. VEGF and EGFR counts were evaluated with immunohistochemistry. Results showed a significant difference was found between VEGF in control and treatment groups demonstrated by considerably increased VEGF count in the treatment groups. There was a significant difference in EGFR in control group compared to that in treatment group with evidence of considerably greater EGFR count in treatment group. A significant difference was found between VEGF and EGFR in deep second degree burns and those in third degree burns, demonstrated by considerably increased VEGF and EGFR count in the latter. There was no significant difference between VEGF and EGFR counts on day 5 and day 10. In conclusion, subcutaneous injection of heparin could promote VEGF and EGFR counts by means of promoting angiogenesis and epithelialization acceleration resulting in wound healing acceleration.

Keyword :

Heparin, burn, angiogenesis, epithelialization,


References :

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Archive Article

Cover Media Content

Volume : 43 / No. : 1 / Pub. : 2007-01
  1. Serum p53 protein and total lymphocyte profile in sepsis patients treated with ciprofloxacin and cefotaxime
  2. Effect of loranthaceae daendropthoe species infusion on serum transaminase level and hepatic necrosis in rats
  3. Glucose 6 phosphate dehydrogenase (g6pd) deficiency in bad pregnancy history in st. vincentius a paulo catholic hospital, surabaya
  4. Heparin effect on vegf and egfr after deep second and third degree burns in rattus novergicus strain wistar
  5. Examination of oxldl serum level as the prognosis of acute thrombotic ischemic stroke
  6. Mental changes in parkinson's disease a study of fifty patients
  7. Microscopic picture and water content in dentin analysis of bonding agent bond to dentin surface an evaluation of various humidity
  8. Localization of plasmodium falciparum asexual stage antigen by mouse immune sera
  9. Description of urinary retention in women a retrospective study in dr soetomo hospital surabaya
  10. Review article: the potential intervention on apoptosis and cell cycle activity in rheumatoid arthritis
  11. Review article: the role of microglia as prime component of cns immune system in acute and chronic neuroinflammation
  12. Review article and clinical experience: a novel “two-in-one” drug fixed combination of ros and met its roles on ir, prediabetes, mets, t2dm and cvd