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Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 35 / No. 1 / Published : 1999-01

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Original Article :

Hpa axis activation and hippocampal atrophy

Author :

      Abstract :

      HPA axis activation begins with an increase in Corticotropin-Releasing Hormone (CRH) secretion by Paraventricular Nucleus (PVN) in hypothalamus and results in the release of adrenal cortex hormone, cortisol. Higher centers, such as cortex and limbic system, also involve in this reaction, especially the amygdala and hippocampus. Generally, hippocampus has inhibiting effect towards HPA axis. On the other hand, central nucleus of amygdala involves in the stimulation of HPA activity by stressors through direct projection to PVN. The lessening of hippocampal pyramidal neurons was first noticed in aging rats. Adrenalectomy performed on middle-aged rat can halt this process, while administration of glucocorticoid for 12 weeks resulted in neuronal loss in hippocampal formation. Chronic social stress can also decrease the amount of hippocampal neurons in monkeys. This effect differs for various areas in hippocampus according to the type of stressor. The decrease in hippocampal volume related to glucocorticoid and stress can be the result of neuronal loss or other structural changes that does not necessarily mean damage. Recent evidence shows there is reversible function and structural plasticity in adult hippocampus as the result of adrenal steroid activity. Stress-induced hippocampal atrophy can be blocked by various means: (1) inhibition of release and action of excitatory amino acids by phenytoin; (2) enhancement of serotonin reuptake by tianeptine; and (3) inhibition of adrenal steroid synthesis in stress response.

      Keyword :

      HPA axis, hippocampus, stress, hippocampal atrophy,


      References :



           


        Archive Article

        Cover Media Content

        Volume : 35 / No. : 1 / Pub. : 1999-01
        1. History And Concept Of Psychoneuroimmunology
        2. Psychobiological Basis Of Psychoneuroimmunology
        3. Psychobiology Of Stress
        4. Neurobiological Basis Of Consciousness
        5. Hpa Axis Activation And Hippocampal Atrophy
        6. Development Of Psychoneuroimmunological Concept
        7. Body Defense Profile As Indicator Of Threshold Value Of Susceptibility To Illness. A Psychoneuroimmunological Study On Indonesian Haj Pilgrims.
        8. Influence Of Circadian Rhythm Changes On Innate Immunity Response
        9. Laser Biomodulation On Immune Response In Reversible Pulpitis
        10. Role Of “inner Power” Healing As A Traditional Culture In Strengthening The Community Health Status