UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 3 / Published : 2008-07

Order : 2, and page :138 - 144

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Original Article :

Ifn-γ in peripheral blood mononuclear cells and bronchoalveolar lavage patients with pulmonary tuberculosis before and after treatment with oral anti-tuberculosis drugs

Author :

  1. JF Palilingan*1
  1. Department of Pulmonology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Jl Mayjen Mustopo 6-8, Surabaya 60286

Abstract :

Results of cytokine production by human T cells in response to Mycobacterum tuberculosis vary widely between studies. The present study was to determine the profile of the Th1 immune response in pulmonary tuberculosis during treatment. Nine male patients with M. tuberculosis culture positive pulmonary tuberculosis were studied. IFN-g cytokine was measured by ELISA from culture of peripheral blood mononuclear cells and bronchoalveolar lavage fluid cells with purified protein derivative (PPD). Only nine patients completed the study.  The result of IFN-g in PBMC before treatment after challenged with PPD was 5705.33 pg/ml and 10682.71 pg/ml after treatment with oral anti-tuberculosis (OAT). The result of IFN-g  in BAL fluid after challenged with PPD was 10855.33 pg/ml and 27.17 pg/ml after completion the chemotherapy. Changes in the IFN-g cytokine profile to Th1 in PBMC patients after treatment conflicted with the result from the BALF cells. This study showed that in these patients the Th2 immune response still present at the site of the disease.

Keyword :

pulmonary tuberculosis, Th1/Th2, IFN-, PBMC, BALF,


References :

Baecher-Allan, C, Brown, JA, Freeman, GJ, Hafler, DA,(2001) CD4+CD25 high regulatory cells in human peripheral blood - : J Immunol

Barnes, PF, Mistry, SD, Cooper, CL, Pirmez, C, Rea, TH, Modlin, RL,(1989) Compartmentalization of a CD41 T lymphocyte subpopulation in tuberculous pleuritis - : J Immunol

Boras, Z, Juretic, A, Gagro, A, Pavelic, L,(2007) Cytokine profile of T lymphocytes from peripheral blood and bronchoalveolar lavage fluid in patients with active pulmonary tuberculosis - : Scand J Immunol





Archive Article

Cover Media Content

Volume : 44 / No. : 3 / Pub. : 2008-07
  1. Effect Of Hsp70 Expression On T-cd4+ Lymphocyte Apoptosis In Hiv/aids Infection
  2. Ifn-γ In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  3. Effect Of Cigarette Smoke Exposure On The Expression Of Mutant P53 In Transitional Cells Of The Bladder An Experimental Study On Rattus Norvegicus
  4. Effect Of High Salt (sodium Chloride) Intake On Fracture Risk In Male White Rats (rattus Norvegicus) An Experimental Laboratory Study
  5. Vibrio Cholerae And Its Typing Profile
  6. Change Of Il-1 Concentration And Intracellular Calcium (ca2+ Ic) As An Indicator Of Increased Bitter Taste In Thypoid Fever
  7. Enriching Communication Behavior Change Framework With Religious Element To Increase Compliance In Taking Anti-tuberculous Drugs
  8. Cognitive Function Disorder As A Reflection Of Immunity Status In People Living With Hiv/aids
  9. Lactate Dehydrogenase Level And The Response Of Non Hodgkin Lymphoma Patients To Chemotherapy Cyclophosphamide Doxorubicin, Vincristine, Prednisone (chop) An Observational, Prospective, Cross-sectional Study At The Department Of Internal Medicine, Dr Soetomo Hospital, Surabaya
  10. Fibular Autostrutgraft As The Optional Treatment Of The Femoral Neck Fractures In Surabaya
  11. The Existence Of A Peak In Adolescent’s Height Increments
  12. Review Article And Clinical Experience: Graves’ Disease And Thyroid Storm: Classical And Non-classical (from Formula G/o: P-39.5 – 120 & Bw-score To Formulas Ts-41668 & Cs-7.1.5)
  13. Review Article: The Effects Of Chlamydia Trachomatis Infection On Women’s Reproduction System

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