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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 38 / No. 4 / Published : 2002-10

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Original Article :

Indicator pf cell proliferation activity in cervical cancer

Author :

      Abstract :

      Current assessment of malignancy in cancer cells, particularly those of cervical cancer, is based on cellular morphological approach and tissue structure by means of histopathological examination. The examination is intended to find morphological abnormalities at cellular level, differentiation abnormalities, presence of mitosis and the abnormality of tissue structure. The results of this examination are classified into well, moderately, and poorly differentiation. Although the mechanism of pathobiological change in cell proliferation activity has not been clearly understood, the classifications has been regarded as reflecting the activity of cancer cell proliferation. In order to obtain classification with more established "clinical value", a study using molecular pathobiology approach was undertaken to disclose the basic mechanism of cancer cell proliferation activity in cervical cancer. This study found no significant difference in the expression of p53, pRb, and c-myc in cervical cancer regarding the cellular differentiation. This indicated that molecular pathobiological mechanism of cancer cell proliferation activity did not match with the classification of differentiation or "historical grading" currently used. A new classification based on the level of protein expression in those genes can, therefore, be made in cluster, in which, by means of multivariate test with Wilks Lambda = 0.116 and significance level of p < 0.05, a significant difference was found. Using discriminant analysis of 94.6%, it was found that the discriminator variables were p53 and c-myc. New groupings based on the variables that play role in cell proliferation activity may be used as the basis to develop molecular grading system. The declining role of p53 and pRb in cervical cancer was apparently not caused by mutation, but particularly by the mechanism of gradation and proteolysis at protein level (chaperonin)

      Keyword :

      protein expression, cell proliferation activity, molecular grading system,


      References :



           


        Archive Article

        Cover Media Content

        Volume : 38 / No. : 4 / Pub. : 2002-10
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        2. Review Article And Clinical Experience: Diabetes And Cvd: Double Jeopardy (introduction With Syndrome-36 And Time To Act)*
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        4. Serum Concentrations Of Chloroquine And Tumor Necrosis Factor In Malaria Patients
        5. The Role Of Jamu (indonesian Herbal Medicine) For Facing The Need For Drugs
        6. Correlation Between Clinical Assessment And Routine Laboratory Tests
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        8. Decrease Iga Producing Cells With Imbalance Of Type 2 Cytokines Producing Cells On Mucosal Immune Response Of Vitamin A Deficient Rats. An Experimental Animal Study
        9. Indicator Pf Cell Proliferation Activity In Cervical Cancer
        10. Phonon Interaction Of Ultrasound Waves Against Primary Oocyte Of Albino Rat Ovary (rattus Norvegicus Var. Wistar)
        11. Interleukin-8 In Nasal Lavage Is Increased In Jute Workers With Symptoms Of Byssinosis In A Gunnysack Factory Of Surabaya(1)