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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 1 / Published : 2006-01

TOC : 7, and page :40 - 46

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Original Article :

Multiresistance pattern of extended spectrum β-lactamase (esbl) – escherichia coli and klebsiella pnemoniae strains

Author :

  1. Kuntaman*1
  2. Ni Made Mertaniasih*2
  3. Usman Hadi*3
  1. Department of Microbiology, Airlangga University School of Medicine
  2. Department of Microbiology, Airlangga University School of Medicine
  3. Department of Internal Medicine, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya

Abstract :

All specimens came in the Clinical Microbiology Laboratory of Dr. Soetomo Hospital Surabaya were prospectively studied since January 2005 until April 2005. The bacterial isolation and identification were performed using the standard method on the consecutive isolates. The biochemical reaction was performed by using the reagent of Microbact for Gram negative bacteria detection Microbact 12A (Medveg diagnostics). The susceptibility test was conducted by disk diffusion test according to NCCLS method. The phenotypic confirmation laboratory testing of ESBLs were conducted using ceftazidime disk (CAZ 30 ug) and ceftazidime plus clavulanic acid (CD 30ug/10ug) according to NCCLS and ESBLs determined using double disc (DD) synergy method. Prevalence of ESBL producing Escherichia coli and Klebsiella pneumoniae from clinical specimens were high 34.84 % (115/330) and 35.35% (105/297). Antimicrobial resistance pattern of ESBL-producing E. coli and Klebsiella pneumoniae to third generation cephalosporin were high resistant, i.e.: cefotaxim (90.4%), ceftriaxon (95.7%), ceftazidime (55.7%); 81.9%, 94.3%, 87.8% respectively. The resistance pattern against ciprofloxacin have similar figure with thirds generationcephalosporin. The alternative sensitive drugs against ESBL-producing bacteria were meropenem and fosfomycin.

Keyword :

Extended Spectrum β-Lactamase (ESBL), multiresistance, Escherichia coli, Klebsiella pneumoniae,


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Archive Article

Cover Media Content

Volume : 42 / No. : 1 / Pub. : 2006-01
  1. Toxoplasma gondii infection elicits the increase of fas expression on the trophoblast associated with the increase of trophoblast apoptosis
  2. Effect of laser at pishu point on amount and function of pancreatic β cells (rattus norvegicus) injected by streptozotocin
  3. The effects of unilateral urethral obstruction on tubular cells apoptosis:an experimental study in rabbits
  4. Antimicrobial activities of andrographolide and propolis against intracellular mycobacterium tuberculosis phagocytosed by monocytes derived macrophages
  5. The 2-methoxyethanol toxicity towards the structures of plasma membrane and mitochondria of the rat’s spermatozoa
  6. Genotyping of extended spectrum Β-lactamase escherichia coli strains from clinical specimens
  7. Multiresistance pattern of extended spectrum β-lactamase (esbl) – escherichia coli and klebsiella pnemoniae strains
  8. Fev1-reversibility in house-dust immunotherapy compared with inhaled corticosteroid in the treatment of childhood asthma
  9. Trachoma in pondok pesantren salafiyah syafiiyah, sukorejo, situbondo, east java. a case study
  10. Review article : depression in post-myocardial infarction patients
  11. Review article and clinical experience: the mets: one of the major threat to human health