UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 1 / Published : 2013-01

Order : 5, and page :21 - 25

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Original Article :

Muscle glucose transporter 1 (glut-1) expression in diabetic rat models

Author :

  1. Bambang Purwanto*1
  2. I Ketut Sudiana*2
  3. Lilik Herawati*3
  4. Bimo Aksono*4
  1. Department of Physiology Faculty of Medicine, Airlangga University
  2. Department of Anatomic Pathology Faculty of Medicine, Airlangga University
  3. Department of Physiology Faculty of Medicine, Airlangga University
  4. Departement of Biochemistry, Faculty of Veterinary, Airlangga University

Abstract :

Glucose transporter-1 (Glut-1) is one of glucose transporter which found in skeletal muscle. Not like Glut-4, Glut1 is insulin independent in facilitating glucose diffusion across cell membrane. We suggest that Glut-1 expression in skeletal muscle membrane was not affected in diabetes mellitus. This study was aimed to investigate Glut-1 expression by time in skeletal muscle diabetic rat models. Streptozotocin (STZ) was used to induce diabetes in rat models. Intraperitoneal injection of 150 mg per BW STZ was administered to 18 rats in a single load. We sacrificed every 6 rats after the first, second and third day of STZ induction. Each rat models were analyzed for it blood fasting glucose, pancreas and gastrocnemius muscle. Hyperglycemic (more than 200 mg/dl) were found in the first day until the third day of STZ induction. Blood fasting glucose decreases significantly only at the second day of STZ induction, even though it was still in hyperglycemic range. At the same day, Glut-1 expressions rise significantly at muscle membrane and kept in a high expression until the next day. These findings proved that Glut-1 was not only unaffected but also participating in physiologic defense against metabolic stress in diabetic models. (FMI 2013;49:21-25)

Keyword :

Muscle, Glut-1, expression, diabetes,


References :

American Diabetes Association,(2004) Diagnosis and classification of diabetes mellitus - : Diabetes Care

Ciaraldi TP, Mudaliar S, Barzin A, Macievic JA, Edelman SV, Park KS, Henry RR,(2005) Skeletal muscle GLUT1 transporter protein expression and basal leg glucose uptake are reduced in type 2 diabetes - : J Clin Endocrinol Metab





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