Folia Medica Indonesiana
ISSN 0303-7932
Vol. 44 / No. 4 / Published : 2008-10
Order : 10, and page :274 - 280
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Original Article :
Pharmacokinetic parameters determination of a single 500-mg oral dose of levofloxacin in healthy subjects by using blood data
Author :
- Toetik Aryani*1
- Suharjono*2
- Febri Hari Murti*3
- Department of Clinical Pharmacy, Airlangga University School of Pharmacy
- Department of Clinical Pharmacy, Airlangga University School of Pharmacy
- Department of Clinical Pharmacy, Airlangga University School of Pharmacy
Abstract :
The pharmacokinetic profiles of once daily oral levofloxacin in seven healthy male volunteers were investigated. The aim of the study was to know how pharmacokinetic parameters and pharmacokinetic profiles in Indonesian healthy subjects receiving a single oral 500-mg dose of levofloxacin. Samples were taken minimally 3 times of the drug‘s half life (which was 24 hours). Blood samples were serially drawn at 0, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 4, 5, 8,and 24 hours. Plasma levofloxacin concentrations were assayed by spectrofluorometry at excitation wavelength 295 nm and emission wavelength 496 nm. Pharmacokinetic analysis was performed assuming a open two-compartment model. The pharmacokinetic profiles of levofloxacin 500 mg by using blood data such as AUC0-24 were obtained in the range of 52.74- 88.31 mg.hour/L, AUC0-¥ were obtained in the range of 54.41-69.44 mg.hour/L, Cmaks were obtained in the range of 8.60-10.80 mg/L, tmaks were obtained in the range of 0.50-1.25 hour, b were obtained in the range of 0.08-0.14 hour-1, t1/2b were obtained in the range of 5.02-9.06 hour, α were obtained in the range of 0.38-3.16 hour-1, Cl were obtained in the range of 5.66-9.19 L/hour, and Vd were obtained in the range of 64.73-93.84 L.
Keyword :
levofloxacin, pharmacokinetic profile, pharmacokinetic parameters, blood data, Indonesia,
References :
Chambers, HF,(2001) Antimicrobial agent general consideration, in G Joel, Hardman, L Limbird, AG Gilman (eds), Goodman & Gilman’s The Pharmacological Basic of Therapeutics, 10th edn New York : The McGraw-Hill Company, Inc.
Chambers, HF,(2007) Antimicobacterial drugs, in BG Katzung, Basic Clinical Pharmacology San Fransisco : McGraw-hill Company, Inc.
Chambers, HF,(2007) Sulfonamides, trimethoprim & quinolones, in BG Katzung, Basic Clinical Pharmacology San Fransisco : McGraw-hill Company, Inc.
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