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Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 34 / No. 4 / Published : 1998-10

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Original Article :

Pharmacokinetics of methotrexate in children

Author :

      Abstract :

      Methotrexate, an antifolate drug, has been used in the therapy of human cancer. It has been administered clinically by the intravenous or oral route. Methotrexate is more completely distributed in the tissues of children than adults at the same infused dosage. This may explain the increased tissue toxicity caused by methotrexate. The metabolism of methotrexate which plays a role in the biological effect of the drug is worthy of further investigation.

      Keyword :

      methotrexate, chemotherapy, cancer,


      References :



           


        Archive Article

        Cover Media Content

        Volume : 34 / No. : 4 / Pub. : 1998-10
        1. The Prospect Of Gene Therapy For Thalassemic Patients, A Review
        2. Growth In Indonesian Children Aged 6 To 15 Years
        3. Pharmacokinetics Of Methotrexate In Children
        4. Echocardiography Follow-up After Succesful Percutaneous Transvenous Mitral Commisurotomy (three Years Follow-up)
        5. Catheter Rupture During Angiography (a Case Report)
        6. Occupational Environment And Male Reproductive Health
        7. Prescribing For Cough: The Use Of Antitussive And Expectorants
        8. Jensen Procedure On Paralytic Esotropia Or Lateral Rectus Or N Vi Palsy Caused By Trauma
        9. A Preliminary Report, Staining And Visualization Of Dna In Agarose-gel With Bio-safe Dye
        10. The Use Of Unit Cost Analysis In Health Center Management, A Study In Lawang Health Center