UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 1 / Published : 2011-01

Order : 3, and page :10 - 14

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Original Article :

Protein kinase c: after the combination of metformin and hyperbaric oxygen therapy in type 2 diabetes patients

Author :

  1. Endang Isbandiati*1
  2. Bernadette Dian Novita Dewi*2
  3. Handi Suyono *3
  1. Division of Post Graduated Program of Pharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, Airlangga University, Surabaya Indonesia
  2. Division of Post Graduated Program of Pharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, Airlangga University, Surabaya Indonesia
  3. Division of Post Graduated Program of Hyperbaric Medicine, Department of Physiology, Faculty of Medicine, Airlangga University, Surabaya Indonesia

Abstract :

Metformin improves not only insulin sensitivity but also vascular endothelial functions and reduces cardiovascular events in patients with type 2 diabetes. Hyperbaric oxygen therapy (HBO therapy), 2.4 ATA reduces directly blood glucose by using glucose to produce energy (ATP), has effect on vasodilatation by stimulating Nitric Oxid Synthase (NOS) and presumably improves Insulin sensitivity via AMPK activation. Therefore, HBO is considered as an adjuvant treatment in type 2 DM beside Metformin. Protein kinase plays a role in translocation of GLUT4 vesicles to cell surface. In this study, we investigated the role of Protein Kinase C in insulin-induced GLUT4 in improving glucose blood reduction. The aim of this study was to find a new management in metformin therapy optimalisation in patients with type 2 diabetes, especially in reducing blood glucose, and improving PKC’s concentration. It is believed that the progresivity of diabetes depends on PKC appearance and activity and the improvement of insulin sensitity effects on GLUT4. This was a pre and post experimental clinical study without control. Ten male correspondents were chosed randomly. Blood glucose and PKC concentrations were used as the parameters, examined before, during and after combined treatment of Metformin and HBO therapy were given. Glucose blood reduced significantly after the therapy. PKC’s titer had no significant change before and after treatment. Conclusion: Metformin and OHB therapy reduce blood glucose but not significantly increase PKC’s concentration. The specific ways of Metformin and OHB therapy’s effect should be explored more. The clinical implications of these combination therapies remain to be determined.

Keyword :

Metformin, OHB therapy, PKC, glucose blood,


References :

Bailey C,(2007) Treating insulin resistance: future prospects - : Diab Vasc Dis Res

Dipiro JT., Talbert RL., Yee GC., Matzke GR, Wells BG., Posey LM.,(2009) Pharmacotherapy : A Pathophysiologic Approach 7th Ed NY : Mc. Graw Hill Companies, Inc.

Goodman & Gilman A,(2006) The Pharmacological Basis of Therapeutics, 11th ed NY : The Mc Graw-Hill Companies, Inc.





Archive Article

Cover Media Content

Volume : 47 / No. : 1 / Pub. : 2011-01
  1. Evaluation Of Burn Unit Gbpt Performance From 2006-2008. A Retrospective Study
  2. Sex Determinant Of Human Hair With Dna Analysis Method Using Polymerase Chain Reaction (pcr)
  3. Protein Kinase C: After The Combination Of Metformin And Hyperbaric Oxygen Therapy In Type 2 Diabetes Patients
  4. Effectiveness Omeprazole And Lansoprazole In Dyspepsia Patient With Nepean Dyspepsia Index
  5. Decrease Of Cross Shift And Cross Week Blood Cholinesterase Activity In Pesticide Sprayer Of Onion Farmers
  6. Identification Of Mycobacterium Tuberculosis Adhesion Protein In Sputum Of Tuberculous Patients
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  8. Review Article: Reducing Maternal Mortality Rate (mmr) And Infant Mortality Rate (imr): Non Institutional Delivery Or Institutional Delivery?
  9. Maternal Risk Factors Of Premature Delivery In Dr Soetomo Hospital
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  11. Difficulty In Achieving Hemodialysis Adequacy In Hemodialysis Unit, Dr. Soetomo Hospital, Surabaya, Indonesia
  12. Acute Toxicity Test Of Bark And Stem Ethanol Extract Of Sopang (caesalpinia Sappan Linn) By Brine Shrimp Lethality Test
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