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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 4 / Published : 2013-10

TOC : 1, and page :202 - 207

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Original Article :

Relationship between n-terminal pro-brain natriuretic peptide (nt-probnp) level and protein st2 level in acute coronary syndrome patient

Author :

  1. Trinandika Ardhana*1
  2. M Aminuddin*2
  3. Jusak Nugraha*3
  1. Genteng General Hospital, Genteng, Banyuwangi, East Java, Indonesia
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Protein ST2 has a pluripotent role and participates in immunology process, as well as in fibrotic of heart as response to injury. TheST2 gene encodes two isoforms of ST2 protein, trans-membrane (ST2L) and soluble, circulating (sST2) induced in cardiomyocytesand fibroblasts by biomechanical stress. sST2 is considered a novel biomarker for cardiac strain. N-Terminal Pro-Brain NatriureticPeptide (NT-proBNP) is released as a response of wall stress and myocyte stretch. Plasma concentration of NT-proBNP rises rapidlyover the first 24h after acute myocardial infarct then declines, and exhibit a second rise after five days, possibly related to adverseremodeling. When measured either at the time of initial presentation onset of ACS, the blood concentration of NT-proBNP is stronglyand independently associated with the short- and long-term risk of death and heart failure. Our objective is to analyze correlationbetween serum level of Protein ST2 and NT-proBNP on Acute Coronary Syndrome (ACS) patient. This is an observational study of34 Acute Coronary Syndrome Patient in Emergency Room and ICCU dr Soetomo Hospital. Quantikine® human ST2/IL-1 R4Immunoassay was used to measured protein ST2 concentrations with ELISA method and RELIA TM Immunoassay DiagnosticInstrument (SSJ-2) Kit was used to measured NT-proBNP concentrations with ELISA method, 1 hour after admission. The proportionof NTproBNP between normal category and second class is almost the same, namely 32,4% and 35,3%. The lowest proportion isowned by fourth class, which is 8,8%. There was correlation between peak ST2 and Amount of NT - pro BNP elevation.(FMI2013;49:202-207)

Keyword :

Acute Coronary Syndrome, ST2, NT-proBNP,

References :

  1. Arakawa N, Nakamura M, Aoki H, Hiramori K, (1994). Relationship between plasma level of brain natriuretic peptide and myocardial infarct size. - : Cardiology
  2. Chan D and Ng LL, (2010). Biomarkers in acute myocardial infarction. - : BMC Med


Archive Article

Cover Media Content

Volume : 49 / No. : 4 / Pub. : 2013-10
  1. Relationship between n-terminal pro-brain natriuretic peptide (nt-probnp) level and protein st2 level in acute coronary syndrome patient
  2. The effect of lime peel extract (citrus aurantifolia) to total blood cholesterol levels of mice (mus musculus) that given the high cholesterol diet
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