UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 1 / Published : 2007-01

Order : 10, and page :49 - 53

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Original Article :

Review article: the potential intervention on apoptosis and cell cycle activity in rheumatoid arthritis

Author :

  1. Joewono Soeroso*1
  1. Department of Internal Medicine Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

RA (rheumatoid arthritis) is a chronic progressive polygenic multifactor autoimmune disease with a high socioeconomic burden. The regulation of cell death and proliferation is vital for homeostasis, but the mechanisms that coordinately balances these two events in rheumatoid arthritis (RA) remains largely unknown. In RA, the synovial lining increases through decreased cell death e, and/or enhanced proliferation. The aberrant decrease in apoptosis and/or increased cell cycle activity of the fibroblast-like and macrophage-like synoviocytes is responsible for the synovial hyperplasia and contributes to the destruction of cartilage and bone. Besides synovial cells, T cells, and mast cells also increase in number and life span, resulting in the increase of macrophage activation, and production of autoantibodies. Recently, numerous molecules that modulate apoptosis and cell cycle have been implicated to play a role in RA. This review will describe the current understanding of the molecular mechanisms that govern apoptosis and cell cycle, their relationship to RA pathogenesis, and the potential intervention in the treatment of RA.

Keyword :

potential intervention, apoptosis, cell cycle, Rheumatoid Arthritis,


References :

A Ashkenazi,(1998) Death receptors: Signaling and modulation no info : Science

VM Dixit,(1998) Death receptors: Signaling and modulation no info : Science

N Bidère,(2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF). Relocation in T lymphocytes entering the early commitment phase to apoptosis no info : J Biol Chem

AI Catrina,(2002) Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium no info : Ann Rheum Dis

CA Dinarello,(2000) Proinflammatory and Anti Inflammatory Cytokines in Rheumatoid Artrhritis no info : Amgen Inc.

LL Moldawer,(2000) Proinflammatory and Anti Inflammatory Cytokines in Rheumatoid Artrhritis no info : Amgen Inc.

K Fujii,(2001) CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells no info : J Immunol

Y Fujii,(2001) CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells no info : J Immu



Archive Article

Cover Media Content

Volume : 43 / No. : 1 / Pub. : 2007-01
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  6. Mental Changes In Parkinson's Disease A Study Of Fifty Patients
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  8. Localization Of Plasmodium Falciparum Asexual Stage Antigen By Mouse Immune Sera
  9. Description Of Urinary Retention In Women A Retrospective Study In Dr Soetomo Hospital Surabaya
  10. Review Article: The Potential Intervention On Apoptosis And Cell Cycle Activity In Rheumatoid Arthritis
  11. Review Article: The Role Of Microglia As Prime Component Of Cns Immune System In Acute And Chronic Neuroinflammation
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