UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 2 / Published : 2009-04

Order : 13, and page :165 - 173

Related with : Scholar   Yahoo!   Bing

Original Article :

Review article and clinical experience: emerging multiple properties of high dose thiamine and b6-b12 vitamins therapeutic possibilities for diabetic vascular complications

Author :

  1. Askandar Tjokroprawiro*1
  1. Diabetes and Nutrition Centre, Dr. Soetomo Teaching Hospital, Airlangga University School of Medicine, Jl Mayjen Mustopo 6-8, Surabaya

Abstract :

High prevalence of low plasma thiamine level in diabetes (T1DM and T2DM) linked to a marker of vascular disease. The deficiency of thiamine in diabetes increases the susceptibility of vascular cells to the injurious effects of hyperglycemia (“PAHA” and “PAHAM”), and hence increased the risk of developing microvascular complications. Thiamine supplementation to high dose as adjunct therapy may prevent the development of vascular complications in clinical diabetes, also may result in the reversal of diabetic dyslipidemia. One of the most important function of B6 Vit is to suppress the activation and translocation of NFkB. The combination of B12 Vit and folate show the protective effects on the developments of myocardial infarction and stroke. In conclusion, the FDC drug Neurobion® show several therapeutic possibilities with multiple clinical benefits for patients with diabetes mellitus. Thiamine repletion with thamine or benfotiamine may prevent or delay the development of diabetic microvascular complications in vivo.

Keyword :

thiamine, B6-B12 vitamines, diabetic vascular complications,


References :

Arora, S, Lidor, A, Abullarage, CJ, Weiswasser, JM, et al,(2006) Thiamime (vitamin-B1) improves endothelium-dependent vasodilation in the presence of hyperglycemia - : Ann Vasc Surg

Avena, R, Arora, S, Carmody, BJ, Cosby, K, & Sidawy, AN,(2000) Thiamine (vitamin B1) protects again glucose – and insulin-mediated proliferation ofhuman infragenicular arterial smooth muscle cell - : Ann Vasc Surgery

Guzik, TJ, Mussa, S, Gastaldi, D, Sadowski, J, et al,(2002) Mechanism of increased vascular superoxide production in human diabetes mellitus - : Circulation





Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2009-04
  1. Correlations Between Hip Abductor’s Performance With Hip Bone Mineral Density In Elderly Women
  2. 14.5 Kda Protein Of Plasmodium Falciparum Is A Specific Asexual Stage Antigen Recognized By Pooled Of Mouse Immune Sera
  3. The Expression Of Mitochondrial Heat Shock Protein 10 In Oral Lesions With Hpv Positive
  4. Nosocomial Infection Monitoring Using Urine Catheter
  5. Pattern Of Community Role Development As An Effort To Increase Tuberculosis Patients Coverage With Passive Case Finding
  6. Effectiveness Of Cigarette Butts As An Alternative Material For Forensic Dna Identification With Polymerase Chain Reaction (pcr) In Short Tandem Repeat (str) Loci
  7. Effect Of Friction Technique Massage For Leg After Maximal Exercise On The Removal Rate Of Blood Lactate
  8. Physiological Effects Of Music During Exercise Secretion Of Hormones Cortisol And Endorphins
  9. Expression Of P53 Oncoprotein In Human Ductal Breast Carcinoma (in Situ, Invasive And Metastatic)
  10. Review Article : Congenital Heart Disease. The Holistic Approach, Now And  In The Future In Indonesia
  11. Review Article: Management Of Subclinical Ventricular Dysfunction
  12. Review Article: Exercise And Brain Health In Elderly
  13. Review Article And Clinical Experience: Emerging Multiple Properties Of High Dose Thiamine And B6-b12 Vitamins Therapeutic Possibilities For Diabetic Vascular Complications