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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 2 / Published : 2005-04

TOC : 8, and page :118 - 129

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Original Article :

Risk factors of symptomatic and asymptomatic osteoarthritis of the knee

Author :

  1. Joewono Soeroso *1
  2. Leonila F Dans *2
  3. Maria Lourdes Amarillo *3
  4. Gina Santoso*4
  1. Department of Internal Medicine, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya, Indonesia
  2. Clinical Epidemiology Unit, University of The Philippines, Manila, The Philippines
  3. Clinical Epidemiology Unit, University of The Philippines, Manila, The Philippines
  4. Department of Internal Medicine, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya, Indonesia

Abstract :

Objective: To determine the risk factors of osteoarthritis (OA) of the knee. Design: Unmatched case-control study. Setting: Dr.Soetomo Hospital Surabaya, a tertiary government hospital. Methods: 239 cases of symptomatic - radiographic (Kellgren-Lawrence I or more) OA of the knee taken from rheumatology out-patient clinic, and 175 cases of asymptomatic - radiographic (Kellgren-Lawrence I or more) OA of the knee and 279 controls without radiographic (Kellgren-Lawrence 0) OA of the knee taken from General Internal Medicine Out-patient Clinic at the same hospital were analyzed through multiple logistic regressions. Group compared: A. Symptomatic cases compared to controls. B. Asymptomatic cases compared to controls. C. Their women subsets compared to that of controls. Results: 1) Symptomatic cases compared to controls: age > 50 (aOR:1.86, 95% CI:1.78-2.82), being female (aOR: 2.08,95% CI: 1.35-3.50), BMI > 25 units (aOR: 3.28,95% CI: 2.20-4.89), elementary education (aOR:0.29, 95% CI:0.14-0.61), genu valgus (aOR: 4.07, 95% CI:2.43-7.93). 2) Women subset of symptomatic cases compared to that of controls: age > 50 (aOR:9.34,95% CI:4.77-18.24), BMI > 25 units (aOR: 5.27,95% CI:2.85-9.73), genu valgus (aOR: 13.64, 95% CI:4.58-41.44). 3) Asymptomatic cases compared to controls: age > 50 (aOR: 2.31,95% CI:1.53-3.50),BMI > 25 units (aOR: 1.57,95% CI: 1.02-2.45). 4) Women subset of asymptomatic cases compared to that of controls: age > 50 (aOR 2.07, 95% CI: 1.14-2.77). Conclusions: 1.Age > 50, being female, BMI > 25 units, genu valgus, are the risk factors for symptomatic OA of the knee 2. Age > 50 and BMI > 25 units are the risk factors for asymptomatic OA of the knee. 3. Being female, BMI > 25 units, genu valgus may be the factors that associated with the development symptoms of OA of the knee.

Keyword :

osteoarthritis, risk factors, knee, symptomatic, asymptomatic,


References :

  1. Bierman EL and Hirsch J, (1981). Obesity In: Williams RH ed. Textbook of endocrinology 6th ed. Philadelphia : WB Saunders Company
  2. Darmawan J, Wirawan S. Soenarto P, Soeharjo H, (1987). Prevalence of rheumatic diseases in rural population in Central Java, Indonesia (Indonesian) In: Tanwir JM, Pramudyo P,Tohamuslim A eds. Symposium of Rheumatology . Bandung : Padjadjaran University


   


Archive Article

Cover Media Content

Volume : 41 / No. : 2 / Pub. : 2005-04
  1. Editorial vol 41 no 2 2005
  2. Opinion: bioethics. its role in research
  3. Gastroprotective effect of curcumine on ethanol-induced gastric mucosal lesions in rats
  4. Spermatozoa motility and morphological recovery process in mice (mus musculus) after the induction of 2-methoxyethanol
  5. Nutritional and immune effects of early enteral feeding supplemented by arginine, glutamine and omega 3 fatty acid in critically ill patients
  6. The comparison of the effectiveness between 2.5% povidone-iodine eye drop and 1% tetracycline eye ointment on bacterial ophthalmia neonatorum prophylaxis
  7. The effectiveness test of eyedrop lodoxamide tromethamine 0.1 % and sodium cromoglycate 2% in vernal keratoconjunctivity in dr. soetomo hospital, surabaya
  8. Risk factors of symptomatic and asymptomatic osteoarthritis of the knee
  9. Brain natriuretic peptide as an indicator of left ventricle dysfunction and a predictor of cardiovascular events in acute coronary syndromes
  10. Management of perioperative pulmonary edema in patient with pre-eclampsia/eclampsia undergoing c-section
  11. Water source as the risk factor of h. pylori infection in chidren aged 0 - 5 years in suburban area of surakarta
  12. Clinical–epidemiological data on hiv/aids patients admitted to a top referral hospital during 1997-2005. a database for action in the future, referring to another developing countries
  13. Review article and clinical experience: new insights into oral agents in the treatment of t2dm (the roles of fixed-dose oral agents combination)
  14. Literature review: choosing a prosthetic heart valve