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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 4 / Published : 2011-10

TOC : 2, and page :207 - 210

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Original Article :

Sensitivity and specificity of clinical features of influenza like illness and laboratorical findings for diagnosed influenza a (h1n1) in children

Author :

  1. Retno Asih Setyoningrum*1
  2. Herwina Brahmantya*2
  3. Dwi Putri Lestari*3
  4. Landia Setiawati*4
  1. Department of Child Health, Faculty of Medicine, Airlangga University
  2. Department of Child Health, Faculty of Medicine, Airlangga University
  3. Department of Child Health, Faculty of Medicine, Airlangga University
  4. Department of Child Health, Faculty of Medicine, Airlangga University

Abstract :

Indonesian Health Department based on guidelines of WHO-Centers for Disease Control and Prevention had published a guidelines for diagnosed influenza A (H1N1) virus infection, with a gold standart of PCR specimen. Prompt diagnosis and intensive therapy was associated with favourable outcomes. A simple tools was need for early diagnosed to confirmed the PCR result. This study was to explore the strength of clinical features of inluenza like illness and laboratorical findings as a predictor of influenza A (H1N1) in children. This was a retrospective case-control study was carried out among children with suspected case of influenza A H1N1 admitted to Soetomo hospital from July to September 2009. Confirmed influenza A H1N1 patient define based on rt RT-PCR H1N1 of specimen from nasopharyngeal swab. Symptoms of influenza like illness and laboratorical findings were noted. The data was analyzed using X2 test. We found that within 83 patients admitted with suspected influenza A H1N1, 52 cases (67.2%) were confimed. Cough was found at 81 cases (97.6%), with fever at 50 cases (60.2%) and from laboratorical findings there were 40 cases (48.2%) with lymphopenia. Cough with fever had significant association with confirmed case of influenza A H1N1 (p=0.047;LR 3.92;CI 95%;1.002-6.238), with sensitivity and spesificity 71% and 50% (PPV=67%;NPV=55%). Cough with fever and lymphopenia was associated with confirmed case of influenza A H1N1 (p=0.009;LR=7.21;CI 95%; 1.359-10.089), with sensitivity 79% and spesificity 49% (PPV=52%; NPV=77%). In conclusion, clinical sign of cough with fever and laboratorical findings of lymphopenia related with positive results of rt RT-PCR. Cough with fever and lymphopenia is better to predict confirmed case of influenza A H1N1.

Keyword :

children, clinical features, laboratorical findings, influenza A H1N1,


References :

  1. Ong AK, Chen MI, Lin L, et al, (2009). Improving the clinical diagnosis of Influenza- a comparative analysis of new influenza A (H1N1) cases. - : Plos one
  2. Park SI, Kim MJ, Hwang HY, Oh CI, Lee JH, Park JS, (2009). Clinical Characteristics of children with 2009 pandemic influenza A (H1N1) admitted to a single institution. - : Korean J Pediatr
  3. Sriram P, Kumar M, Renitha R, Mondal N, Bhat VB, (2010). Clinical profile of swine flu in children at Puducherry. - : Indian J Pediatr
  4. Trifonov V, Khiabanian H, Rabadan R, (2009). Geographic dependence, surveillance, and origins of the 2009 Influenza A (H1N1) Virus. - : N Engl J Med
  5. Depkes, (2009). Pedoman Diagnosis dan Penatalaksanaan Influenza A Baru (H1N1) . - : Depkes RI


   


Archive Article

Cover Media Content

Volume : 47 / No. : 4 / Pub. : 2011-10
  1. Antibiotic resistance control program (arcp) improving antibiotic use in pediatric hematology and oncology patients at dr soetomo hospital in 2006 and 2008
  2. Sensitivity and specificity of clinical features of influenza like illness and laboratorical findings for diagnosed influenza a (h1n1) in children
  3. Risk factors for birth asphyxia
  4. Liver involvement in children with dengue infection
  5. Mechanical ventilation vs nasal cpap duration and the risk of late onset sepsis in premature babies with respiratory distress syndrome
  6. Nucleic acid amplification of the rpob region of mycobacterium tuberculosis in pulmonary tuberculosis diagnosis
  7. Effect of oral-estrogen conjugate on b-lymphocyte proliferation in the peyer’s patches of adult female balb/c mice ileum
  8. The effect of emotional quality management on stress, and optimism in women with breast cancer
  9. Quality and efficiency improvement of professional medical doctor education in public health field using objective structured public health examination (osphe) approach at faculty of medicine airlangga university
  10. Review article: role of ve-cadherin in vascular permeability regulation
  11. Depth of human hypophysial fossa due to aging process: a morphologic research