UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 4 / Published : 2005-10

Order : 9, and page :299 - 305

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Original Article :

Systemic lupus erythematosus associated with cholestatic hepatitis in a child. a case report

Author :

  1. Zahrah Hikmah*1
  2. Ariyanto Harsono*2
  1. Department of Child Health Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Child Health Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Systemic Lupus Erythematosus is an autoimmune disease with the prevalence in children approximately 1 per 100,000. The clinical manifestations are divers, and hepatic involvement is very rare. The patient was a 12 years old girl, admitted to the hospital with the main complaint of prolonged fever and jaundice. Physical and laboratory examinations found 6 criteria of American Rheumatism Association for SLE, justify the diagnosis of SLE. Liver function tests yielded: direct bilirubin 5.36 and total bilirubin 6.82; ALT 565 IU/L and AST 77 IU/L. Viral hepatitis markers were negative. Histopathology examination of liver tissue revealed periportal lymphocytic infiltration, ballooning degeneration, disarray of porta hepatica, and intra-cytoplasmic bilirubin. Prednison induction was given with a dosage 2 mg/kg/day for 30 days. Theoretically combination with azathioprine may give best result, but in this case prednisone alone resulted a good response after 1 week, and consideration of hepatotoxic effect of azathioprine, so azathioprine was cancelled. The results of treatment was good, the patient was discharged from the hospital uneventfully. There is still possibility of relapse.

Keyword :

systemic Lupus Erythematosus, cholestasis, hepatitis,


References :

Hallequa DS, Wallace DJ,(2002) Gastrointestinal and hepatic manifestation. In: Wallace DJ, Hannahs BH. Dubois' Lupus Erythemathosus 6th Ed Philadelphia : Williams and Wilkins

Klein MS, Gitelman, Miller ML,(2003) Systemic Lupus Erythematosus. In Behrman RE, Kliegman RM, Jenson HB. Nelson Textbook of Pediatric 17th Ed Philadelphia : -





Archive Article

Cover Media Content

Volume : 41 / No. : 4 / Pub. : 2005-10
  1. Editorial Vol 41 No 4 2005
  2. Opinion: Trend Of Indonesian Nurse’s Role In The Future
  3. Eosinophilia In Physical Exercise Stressor: Pathobiology Or Physiobiology?
  4. The Detection Of Staphylococcus Aureus In Swiftlets' Nest Using Immunohistochemistry (streptavidin Biotin)
  5. The Role Of Intravenous N-acetylcysteine Reduces Pulse Pressure In Patients With Chronic Kidney Disease Stage 5 During Hemodialysis. A Randomized Blinded Trial
  6. Low Fat Milk V/s Low Lactose Milk For Patients With Different Nutritional Status Who Suffered From Acute Diarrhea
  7. Thymidilate Synthase Polymorphisms In Indonesian Childhood Acute Lymphoblastic Leukemia
  8. Modulation Of Immune Response In Long-term Use Of Inhaled Corticosteroid In Childhood Asthma Receiving Specific Immunotherapy
  9. Systemic Lupus Erythematosus Associated With Cholestatic Hepatitis In A Child. A Case Report
  10. Review Article And Clinical Experience: Preventive And Therapeutic Strategies For Osteoporosis (a Highly Efficacious Risedronate-35 Mg Once Weekly)
  11. Immunological Aspect On Bone Cells
  12. Three Dimension Decision For Statistical Testing. The Significance Of Traditional Medicine Holistic Approach (a Preliminary Idea)
  13. Total Quality Management (tqm), The Best Method To Eliminate Narcotics And Psychotropics Abuse And Illegal Distribution

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