UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 40 / No. 1 / Published : 2004-01

Order : 7, and page :28 - 34

Related with : Scholar   Yahoo!   Bing

Original Article :

The adherence to prescribing guidelines: a drug utilization evaluation of tramadol (a study at the royal brisbane hospital – australia)

Author :

  1. Bambang Subakti Zulkarnain*1
  1. Department of Biomedical Science Airlangga University School of Pharmacy

Abstract :

Objective: To evaluate the adherence to the Guidelines For Prescribing Tramadol as a potent narcotic analgesic. Methods: A drug utilization evaluation was performed to identify whether the prescribing of tramadol meeting the guideline criteria. The primary objective was to assess whether the tramadol was prescribed appropriately i.e. clinical situations, oral doses, and whether it was used with any other concurrent opioids. A secondary objective was to monitor either side effects and/or drug interactions occurred. The primary outcome measure was the number of prescriptions meeting current guidelines. Results: A total of 75 patients on tramadol were identified. The adherence was identified for 52% of tramadol prescriptions. Those were not complying guidelines (48%) mostly from patients not under the care of the Acute Pain Management Service (APMS). Failing to prescribe in the appropriate clinical situations and the use of concurrent opioids were the two most common reasons. No serious reported adverse events of tramadol were found even for the patient exceed intravenous daily dose. Likewise, there were some patients on tramadol and other drugs that could possibly interact. Conclusions: The improvement for prescribing tramadol under guidelines criteria at RBH particularly those not under the care of the APMS through education to medical staff should be addressed. The issue of potential drug interactions and adverse events associated with tramadol should not be left unaware.

Keyword :

Drug Utilization Evaluation, Tramadol, serious Adverse Drug Reactions (ADR),


References :

  1. Oam JT. APP, (2002). Guide: Australian Prescription Product Guide. 31st ed. Vol. L – Z . Melbourne : Australian Pharmaceutical Publishing Company Limited
  2. Hernandez AF, et. Al, (1995). Fatal moclobemide overdose or death caused by serotonin syndrome? . - : J Forensic Sci




Archive Article

Cover Media Content

Volume : 40 / No. : 1 / Pub. : 2004-01
  1. Editorial vol 40 no 1-2 2005
  2. Opinion: the development of medical education a policy analysis
  3. Aquaporin water channels: physiology and medicine
  4. Dot-eia typhoid test using omp salmonella typhi local phage type antigen to support the diagnosis of typhoid fever
  5. Anesthesia for patients with eclampsia in dr soetomo hospital surabaya
  6. Facial nerve paralysis caused by birth trauma
  7. The adherence to prescribing guidelines: a drug utilization evaluation of tramadol (a study at the royal brisbane hospital – australia)
  8. Review article and clinical experience: a therapeutic option in the treatment of pre-dm, igt, and t2dm.(the roles of metformin: from basic to clinics)
  9. Cdp choline (citicoline = nicholin) therapy on some cases of children with organic brain syndrome
  10. Eradication of cholesteatoma and hearing reconstruction in malignant chronic otitis media
  11. Hypertension management from nutritional and exercise perspectives: a case study