UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 1, and page :63 - 66

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Original Article :

The effect of 3000 mg intravenous vitamin c on serum nitric oxide level of severe burnt injury patients

Author :

  1. Lobredia Zarasade*1
  2. Bobby Swadharma Putra*2
  3. Iswinarno Doso Saputro*3
  1. Dosen Fakultas Kedokteran
  2. Department of Surgery, Lampung University
  3. Dosen Fakultas Kedokteran

Abstract :

Nitric oxide (NO) has a potential role to cause systemic hypotension and apoptosis, contributing to tissue damage and multipleorgan failure in severe burnt. Antioxidative effect of Vitamin C supreses free radical formation, blocks pro-inflammatory cytokinerelease and inhibit NO production. The purpose of this research is to review the effect of intravenous vitamin C 3000 mg on serumNO level in severe burnt injury patient post fluid resuscitation. Randomized pre test and post test controlled group designexperimental studied on 12 severe burnts patient at the Burn Unit of Dr. Soetomo Hospital, Surabaya. Samples were divided into 2groups: K1 (control) administered with vitaminC 2x400 mg/24 hour for 72hours; K2, administered with intravenous vitamin C 3000mg for 72 hours. Serum NO level was re-examined by Griess method. The results were analyzed by paired t-test (significant atp<0.05). After research, serum NO level of K1 showed no significant increase compared to day 1 (p=0.21); serum NO level of K2showed no significant decrease compared to day 1 (p=0.06); there is a statistically significant decrease of serum NO level in K2compared to K1 (p=0.02). There was no significant change in Blood Gas Analysis (BGA), Blood Urea Nitrogen (BUN), and SerumCreatinine (SC) on K1. There was significant decreased in White Blood Cell (WBC) on K2 (p=0.01). Administration of intravenousvitamin C 3000 mg/24 hours for 72 hours showed significant decrease in serum NO level of severe burnt patients. (FMI 2014;50:63-66)

Keyword :

vitamin c, severe burnt, nitric oxide,


References :

Çakir B and Yegen BÇ,(2004) Systemic responses to burn injury - : Turk J Med Sci

Chen LW, Hsu CM, Cha MC, Chen JS, Chen SC,(1999) Changes in gut mucosal nitric oxide synthase (NOS) activity after thermal injury and its relation with barrier failure - : Shock





Archive Article

Cover Media Content

Volume : 50 / No. : 2 / Pub. : 2014-04
  1. The Effect Of 3000 Mg Intravenous Vitamin C On Serum Nitric Oxide Level Of Severe Burnt Injury Patients
  2. Correlation Between Plasma Levels Of Interferon And Viral Load In Patients With Hiv Stage 1
  3. Correlation Between Serum Level Of Heart Type Fatty Acid Binding Protein (h-fabp) And N-terminal Pro-brain Natriuretic Peptide (nt-probnp) On Acute Coronary Syndrome Patient
  4. Profile Of Gyra And Gyrb Gene Mutation In Clinical Isolate Of Ciprofloxacin Resistant Pseudomonas Aeruginosa
  5. Effect Of Cardiac Rehabilitation Programs On Functional Capacity Of Post Coronary Revascularization Patient Using Six Minute Walk-test
  6. Correlation Between Tgf-1 Plasma Level And Cd4+ T Lymphocyte Count In Stage I Hiv-infected Patients
  7. The Effect Of 3000 Mg Vitamin C Infusion On Histamine Level Of Severely Burnt Patients
  8. Comparison Of Fugl-meyer Score Between Patients With Acute Thrombotic Infarc Stroke Treated With Standard Medication And Fluoxetine
  9. Antibiotics Quantity-based Escherichia Coli Resistance Pattern In Patients At Surgical And Psychiatric Wards, Dr Soetomo Hospital, Surabaya
  10. Age And Resting Heart Rate Are Discriminators To Predict Endurance Without Physical Test
  11. Case Report: Trunk And Reticular Varicose On A 9-year-old Child
  12. Comparison Of The Apgar Score Of Spontaneous Vaginal Birth And Assisted Birth In Dr. Soetomo Hospital Surabaya
  13. Five Years Retrospective Study Of Burns In Dr Soetomo General Hospital Surabaya