Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 7, and page :96 - 99

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Original Article :

The effect of 3000 mg vitamin c infusion on histamine level of severely burnt patients

Author :

  1. T Purnawan*1
  2. ID Saputro*2
  3. AS Budi*3
  1. Department of Plastic Surgery, Mitra Keluarga Hospital, Surabaya
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

The pathology process in burn injury is both a local and systemic inflammatory reaction, the end result of which is an almostimmediate shift of intravascular fluid into the surrounding interstitial space. This occurs as a consequence of changes in vascularpermeability as the normal capillary barrier is disrupted by a host of mediators, one of them is histamine. Vitamin C functions as ananti-inflammatory on burn by destroying imizadole ring structure of the histamine molecule. The purpose of this research is todetermine the effect of 3000 mg vitamin C infusion on histamine level in severly burnt patients. A randomized pre & posttest controlgroup design. Histamine levels were determined in 16 severely burned patients in burn injury unit of Dr. Soetomo Hospital,Surabaya from June-December 2012 (age 16-65 years old, American Burn Association criteria, 2007). 16 patients were divided into2 groups; G1 (control, given infusion of vitamin C 2x 400 mg per day for 72 hours) and G2 (vitamin C 3000 mg per day for 72hours). Variable examined were histamine level of leucocyte, renal function, and blood gas analysis (BGA).Data were analyzed witht test and coupled t test (significant at p<0.05). G1 histamine level was higher than G2 (p<0.05). There were no significant resultsfrom renal function analysis and BGA between G1 and G2. The amount of G2 leucocyte was lower than G1 (p=0.045). Givingvitamin C infusion with high dose is able to decrease blood histamine level in severely burnt patient. (FMI 2014;50:96-99)

Keyword :

vitamin C, Histamine, severely burned patients,

References :

Evers LH, Bhavsar D, Mailänder P,(2010) The biology of burn injury - : Exp Dermatol

Friedl HP, Till GO, Trentz O, Ward PA,(1989) Roles of histamine, complement and xanthine oxidase in thermal injury of skin - : Am J Pathol

Archive Article

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Volume : 50 / No. : 2 / Pub. : 2014-04
  1. The Effect Of 3000 Mg Intravenous Vitamin C On Serum Nitric Oxide Level Of Severe Burnt Injury Patients
  2. Correlation Between Plasma Levels Of Interferon And Viral Load In Patients With Hiv Stage 1
  3. Correlation Between Serum Level Of Heart Type Fatty Acid Binding Protein (h-fabp) And N-terminal Pro-brain Natriuretic Peptide (nt-probnp) On Acute Coronary Syndrome Patient
  4. Profile Of Gyra And Gyrb Gene Mutation In Clinical Isolate Of Ciprofloxacin Resistant Pseudomonas Aeruginosa
  5. Effect Of Cardiac Rehabilitation Programs On Functional Capacity Of Post Coronary Revascularization Patient Using Six Minute Walk-test
  6. Correlation Between Tgf-1 Plasma Level And Cd4+ T Lymphocyte Count In Stage I Hiv-infected Patients
  7. The Effect Of 3000 Mg Vitamin C Infusion On Histamine Level Of Severely Burnt Patients
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  11. Case Report: Trunk And Reticular Varicose On A 9-year-old Child
  12. Comparison Of The Apgar Score Of Spontaneous Vaginal Birth And Assisted Birth In Dr. Soetomo Hospital Surabaya
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