UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 2 / Published : 2009-04

Order : 3, and page :97 - 101

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Original Article :

The expression of mitochondrial heat shock protein 10 in oral lesions with hpv positive

Author :

  1. Adi Prayitno *1
  2. Widya Asmara *2
  3. Ambar Mudigdo *3
  4. Mandojo Rukmo *4
  5. Suhartono Taat Putra*5
  1. Sebelas Maret University School of Medicine
  2. Gadjah Mada University School of Veterinary Medicine
  3. Sebelas Maret University School of Medicine
  4. Airlangga University School of Dentistry
  5. Airlangga University School of Medicine

Abstract :

Hundreds of studies over the last 25 years have shown that stress contributes to many illnesses including cardiovascular disease, endocrine disease and cancer. Persistent infection with human papilloma-virus may play a central role in cervical carcinogenesis. Cancer may be defined as uncontrolled tissue growth in susceptible patient, with result from imbalance between cell division and program cell death (apoptosis). Psychosocial factors may influence cervical carcinogenesis via a psychoneuroimmunology pathway. Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide. Alcohol/tobacco consumption is the most important risk factor for this neoplasia; nevertheless, since 1983 it has been suggested that human papilloma viruses (HPV) have a role in HNSCC. The aim of this study is to know the protein expression especially heat shock protein 10 in oral lesions with HPV positive. Seventeen samples from many kind oral cavity lesions were collected from 1 January 2007 to 1 November 2007. DNA isolation and diagnose related HPV infections are made by Henk Schmits and/or Nigel McMillan and Nina Fowler method with some modifications. Protein isolation was doing with Vincent and Philippe method with some modifications and the SDS-PAGE protein electrophoresis was doing with 30mA for 6 hour. The result of this experiment was seen the band as 10kDa protein. And the conclusion is the expression oh heat shock protein 10 was up regulated in oral lesion with HPV positive. Certainly the apoptosis process was on.

Keyword :

Stress Cells; HPV; Heat Shock Proteins 10; Apoptosis; Psychoneuroimmunology,


References :

  1. C Garrido, S Gurbuxani, L Ravagnan, G Kroemer, (2001). Heat shock proteins: endogenous modulators of apoptotic cell death . - : Biochem Biophys Res Commun
  2. Claudio Soto, (2001). Protein folding and disease . - : FEBS Letters




Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2009-04
  1. Correlations between hip abductor’s performance with hip bone mineral density in elderly women
  2. 14.5 kda protein of plasmodium falciparum is a specific asexual stage antigen recognized by pooled of mouse immune sera
  3. The expression of mitochondrial heat shock protein 10 in oral lesions with hpv positive
  4. Nosocomial infection monitoring using urine catheter
  5. Pattern of community role development as an effort to increase tuberculosis patients coverage with passive case finding
  6. Effectiveness of cigarette butts as an alternative material for forensic dna identification with polymerase chain reaction (pcr) in short tandem repeat (str) loci
  7. Effect of friction technique massage for leg after maximal exercise on the removal rate of blood lactate
  8. Physiological effects of music during exercise secretion of hormones cortisol and endorphins
  9. Expression of p53 oncoprotein in human ductal breast carcinoma (in situ, invasive and metastatic)
  10. Review article : congenital heart disease. the holistic approach, now and  in the future in indonesia
  11. Review article: management of subclinical ventricular dysfunction
  12. Review article: exercise and brain health in elderly
  13. Review article and clinical experience: emerging multiple properties of high dose thiamine and b6-b12 vitamins therapeutic possibilities for diabetic vascular complications