UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 36 / No. 1 / Published : 2000-01

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Original Article :

The influence of pb-acetate toward the decrease of immunological mucosal system within mus musculus balb/c intestine

Author :

      Abstract :

      This study on influence of lead solution on immunologic system of Balb/C mice's intestinal mucosa aimed to disclose the morphofunction was changes of intestinal mucosal immunologic system, indicated by variables of macrophage, lymphocyte, and immunoglobulin A. Changes occurred were expected to disclose immunopathogenesis of intestinal mucosa due to lead exposure. Mechanism occurred was expected to become a scientific base for preventing further lead exposure to avoid damages in body functions due to more severe and irreversible lead poisoning. This was an experimental study using posttest only control group design, and approached using immunopathobiological concept. Operationalization of this study used three groups. Lead solution in concentration of 100 mg/kg BW was administered to the first group, and the second group was given the same solution in concentration of 25 mg/kg BW. The third group served as control. Lead solution was administered for 8 weeks. Data empirification was obtained from estimation of macrophage, lymphocyte and IgA in intestinal histologic preparation in the area that contained Peyer patch. Data obtained were analyzed using multivariate analysis to find the difference of treatment between groups. Subsequently, discriminant analysis was done to find the strongest differential variable. Results of these analyses were used to describe the intestinal mucosal immune response pattern due to lead exposure. Results showed that influence of lead solution administration to the three groups were significantly different (Wilks, p < 0.05). Result of discriminant analysis showed that the differential variables were macrophage and IgA. It can be concluded that lead may decrease immune response pattern in mice's intestinal mucosa, indicated by variables of macrophage, lymphocyte, and IgA. The decrease occurred in lead solution administration in concentration of 25 mg/kg BW and will be more severe in concentration of 100 mg/kg BW. To disclose the immunopathogenesis in intestinal mucosa due to lead solution administration, we recommend further studies on other changes of intestinal mucosal immunologic system component and on secretory IgA resulted from lead solution exposure.

      Keyword :

      lead intoxication, mucosal immunity, intestine, lymphocyte, macrophage, IgA ,


      References :





      Archive Article

      Cover Media Content

      Volume : 36 / No. : 1 / Pub. : 2000-01
      1. Paradigm And Concept Development Of Pathobiology
      2. Lipoprotein (a) In Thrombotic Ischemic Stroke
      3. From The Other Classes To Angiotensin Ii Receptor Blocker : A Further Step Forward In The Safe Treatment Of Hypertension
      4. The Influence Of Pb-acetate Toward The Decrease Of Immunological Mucosal System Within Mus Musculus Balb/c Intestine
      5. The Analysis Of Ifngamma And Il-10 Levels In Diabetes Mellitus Patients As Oral Candida Albicans Carrier
      6. Clinico-pathological And Serological (iga-anti Vca, Iga-anti Ebna) Studies On Nasopharyngeal Carcinoma Patients In Surabaya
      7. Subchronic Toxicity Studies Of A Mixture Of Ganoderma Lucidum Fruit Body And Mycelium Powder On Wistar Albino Rats
      8. Pharmacodynamic Studies Of Central Nervous System Depressant Effects Of Ligustrosid (a Cns Active Substance Isolated From Fraxinus Griffithii Clarke)
      9. Evaluation Of Urine Blood Cells And Urine Specific Gravity Examination Using The Dipstick Method
      10. Surgical Management Of Non-toxic Multinodular Goiter
      11. The Effect Of Communication, Information And Education (cie) Upgrading Of Elementary School Teachers On The Implementation Of Supplementary Schoolchildren Feeding Provision In Surabaya, East Java

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