Catalog :




Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 36 / No. 4 / Published : 2000-10

Related with : Scholar   Yahoo!   Bing

Original Article :

The pathobiological changes in nasopharyngeal carcinoma treated with radiotherapy and radiotherapy-bcg vaccination combination

Author :

      Abstract :

      The radiotherapy of nasopharyngeal carcinoma (NPC) that is essentially aimed at eradicating all cancer cells, either in the nasopharynx or their metastases in cervical lymph nodes, in fact often gave rise to side effects on the immune system. The decrease of the immune surveillance response will be severely detrimental because it can bring about more progressive cancer growth and metastasis. The ability of effector cells to fight cancer is influenced by the activity of Th1 cells. From several reports of works on tuberculosis, it was known that BCG vaccine could trigger the increase of cell mediated immunity (CMI). To understand the effect of radiotherapy and the advantage of BCG vaccine administration toward the improvement of cellular response of Th1 in the tissues of nasopharyngeal carcinoma (NPC), an experimental pretest-posttest control group design study was carried out. This study involved 77 NPC patients divided into 2 groups: 38 patients were treated with radiotherapy + placebo (control group) and 39 patients were treated with radiotherapy + BCG vaccination (treatment group). The variables studied includes macrophage, NK cells, T CD4 lymphocytes (cT CD4), T CD8 lymphocytes (cT CD8), IL-2 producing T lymphocytes (Tp IL-2), IL-4 producing T lymphocytes (Tp IL-4), IL-10 producing T lymphocytes (Tp IL-10), IFN- producing T lymphocytes (Tp IFN-], IgA producing plasma cells (Pp IgA), IgG producing plasma cells (Pp IgG) and active plasma cells. The obtained data were then treated with Manova test and discriminant test. Based on the obtained patterns, it can be concluded that NPC radiotherapy rendered a decrease of macrophage and NK cells followed by an increase in sPp IgG increase, while the combination of radiotherapy + BCG vaccination caused the macrophage and NK cells to increase followed by a decrease in Pp IgG. BCG vaccination prevented the decrease of Th1 response caused by radiation.

      Keyword :

      nasopharyngeal carcinoma, radiotherapy, BCG vaccination, Th1 response,
      Th2 response
      ,


      References :



           


        Archive Article

        Cover Media Content

        Volume : 36 / No. : 4 / Pub. : 2000-10
        1. The Pathobiological Changes In Nasopharyngeal Carcinoma Treated With Radiotherapy And Radiotherapy-bcg Vaccination Combination
        2. The Effect Of Amphetamine On The Ultrastructure Of The Rat Leydig Cell (rattus Norvegicus L)
        3. Indapamide Sr 1.5 Mg Effect To Microalbuminuria In Mild To Moderate Hypertensive Patients, A Double Blind Randomized Study Compared With Amlodipin 5 Mg In Outpatient Clinic Of Nephrology-hypertension Dr Soetomo Hospital, Surabaya
        4. Pathophysiology Of Vertigo In Accordance With Habituation Phenomenon
        5. Fev-1 Reversibility In Newly Developed Asthma In Children
        6. Response Rate To Chop-cop Therapies In Patients With High And Intermediate Grade Of Non-hodgkin's Lymphoma In Hematology-medical Oncology Outpatient Clinic, Dr Soetomo Hospital, Surabaya
        7. The Impact Of Atherohaemorrheologic Status Improvement On The Quality Of Life Of Non Insulin Dependent Diabetes Mellitus With Peripheral Occlusion Arterial Disease Of The Lower Extremities
        8. Emergency Problem In Acute Head Injury, Assessment And Treatment(1)
        9. Observation Of Infants With Severe Asphyxia For Nine Months In Dr Soetomo Hospital, Surabaya
        10. Adaptation Of Mother’s Card For Integrated Management Of Underfive Illness In East Java Indonesia